INT296837

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.11
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (PTGIS) small molecule metabolic process (PTGIS) endoplasmic reticulum (PTGIS)
lipid metabolic process (PTGIS)
PTGIS (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 14 100.00 Very High Very High Very High
tolerance 2 86.36 High High
aspirin 52 84.96 Quite High
Inflammation 3 83.96 Quite High
cINOD 33 80.56 Quite High
Arthritis 2 60.24 Quite High
cva 4 35.72 Quite Low
Calcium channel 1 22.56 Low Low
adenocard 1 7.76 Low Low
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 89 97.76 Very High Very High Very High
INFLAMMATION 5 83.96 Quite High
Disease 24 83.24 Quite High
Heart Disease 2 72.68 Quite High
Adenoma 1 71.20 Quite High
Influenza Virus Infection 1 70.96 Quite High
Arthritis 3 60.24 Quite High
Thromboembolism 2 36.04 Quite Low
Hypoxia 2 30.40 Quite Low
Apnoea 1 29.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Included in these medications are endothelin receptor antagonists, phosphodiesterase inhibitors, and prostacyclin analogs, such as treprostinil.
Negative_regulation (inhibitors) of Gene_expression (antagonists) of prostacyclin associated with antagonist
1) Confidence 0.17 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC3004515 Disease Relevance 0.63 Pain Relevance 0.09
Although this coxib effect is probably multifactorial, abundant data from experimental models suggest that it derives at in part from suppressed production of prostacyclin (PGI2), especially relative to that of thromboxane (Tx) A2.
Negative_regulation (suppressed) of Gene_expression (production) of prostacyclin
2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824826 Disease Relevance 0.48 Pain Relevance 0.43

General Comments

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