INT296844

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Context Info
Confidence 0.62
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 17
Disease Relevance 10.64
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Atg7) neurological system process (Atg7) cellular amino acid metabolic process (Atg7)
cytoplasm (Atg7)
Anatomy Link Frequency
brains 2
hippocampus 2
neuronal 1
pyramidal neurons 1
neurons 1
Atg7 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 102 99.84 Very High Very High Very High
Hippocampus 85 98.84 Very High Very High Very High
imagery 17 22.36 Low Low
Limbic system 51 5.00 Very Low Very Low Very Low
anesthesia 17 5.00 Very Low Very Low Very Low
Locus ceruleus 17 5.00 Very Low Very Low Very Low
Neurobehavioral 17 5.00 Very Low Very Low Very Low
Substantia nigra 17 5.00 Very Low Very Low Very Low
Immobilon 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 1003 99.84 Very High Very High Very High
Disease 935 99.04 Very High Very High Very High
Targeted Disruption 170 97.20 Very High Very High Very High
Neurodegenerative Disease 153 96.24 Very High Very High Very High
Aging 34 93.44 High High
Infection 85 93.32 High High
Movement Disorders 34 92.92 High High
Dementia 153 92.00 High High
Lewy Body Disease 102 79.36 Quite High
Gauchers Disease 51 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased levels of mTor and reduced Atg7 levels suggest there may be altered activation of the autophagy pathway in the brains of DLB patients.
Gene_expression (levels) of Atg7 in brains associated with parkinson's disease
1) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.90 Pain Relevance 0.09
Immunohistochemical analysis showed moderate levels of mTor and Atg7 immunostaining in pyramidal neurons in control and AD cases (Figure 2A, B, D, E).
Gene_expression (levels) of Atg7 in pyramidal neurons associated with pyramidal cell and disease
2) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.91 Pain Relevance 0.08
In DLB cases, levels of Atg7 were moderately reduced compared to controls and AD cases (Figure 1A, D).
Gene_expression (levels) of Atg7 associated with parkinson's disease and disease
3) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.77 Pain Relevance 0
-syn tg mice levels of mTor were elevated and Atg7 expression was reduced. mTor and LC3 was co-localized with neurons displaying ?
Gene_expression (expression) of Atg7 in neurons
4) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 1.12 Pain Relevance 0
syn, co-expression of Atg7 also resulted in significant activation of autophagy (Figure 10D, E) and a reduction in ?
Gene_expression (co-expression) of Atg7
5) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.09 Pain Relevance 0
The increased levels of mTor and reduced Atg7 levels suggest there may be altered activation of the autophagy pathway in the brains of DLB patients.
Gene_expression (levels) of Atg7 in brains associated with parkinson's disease
6) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.89 Pain Relevance 0.09
Intra-cerebral infusion of rapamycin, an inhibitor of mTor, or injection of a lentiviral vector expressing Atg7 resulted in reduced accumulation of ?
Gene_expression (expressing) of Atg7
7) Confidence 0.54 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2824828 Disease Relevance 1.41 Pain Relevance 0
-syn tg mice treated with the LV-control (Figure 9A–D, G) delivery of LV-Atg7 resulted in increased expression in Atg7 in pyramidal neurons in the hippocampus and in areas adjacent to the injection track in the neocortex (Figure 9E–G).
Gene_expression (expression) of Atg7 in hippocampus associated with pyramidal cell and hippocampus
8) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.32 Pain Relevance 0.15
Overexpression of Atg7 in an In Vitro Model Reduces ?
Gene_expression (Overexpression) of Atg7
9) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0 Pain Relevance 0
Since in addition to the increase in mTor, we also observed a reduction in Atg7 levels in DLB and ?
Gene_expression (levels) of Atg7 associated with parkinson's disease
10) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.37 Pain Relevance 0.10
By immunoblot analysis, compared to controls and AD, in DLB cases levels of mTor were elevated and Atg7 were reduced.
Gene_expression (reduced) of Atg7 associated with parkinson's disease and disease
11) Confidence 0.54 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2824828 Disease Relevance 1.44 Pain Relevance 0
-syn tg mice, we sought to determine whether viral-mediated delivery of Atg7 might also promote ?
Gene_expression (delivery) of Atg7
12) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.37 Pain Relevance 0.11
In the non tg and APP tg mice, immunohistochemical analysis showed moderate levels of mTor and Atg7 immunostaining in pyramidal neurons in the neocortex (Figure 6A, B, D, E, G) and hippocampus (not shown).
Gene_expression (levels) of Atg7 in hippocampus associated with pyramidal cell and hippocampus
13) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.19 Pain Relevance 0.13
-syn, indicating that Atg7 expression specifically reduced the accumulated levels of ?
Gene_expression (expression) of Atg7
14) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.08 Pain Relevance 0
Intra-cerebral infusion of rapamycin, an inhibitor of mTor, or injection of a lentiviral vector expressing Atg7 resulted in reduced accumulation of ?
Gene_expression (injection) of Atg7
15) Confidence 0.47 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2824828 Disease Relevance 1.43 Pain Relevance 0
-syn (Figure 9J, K); in contrast, following LV-Atg7 injection, there was a considerable reduction in the intra-neuronal ?
Gene_expression (injection) of Atg7 in neuronal
16) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.24 Pain Relevance 0.12
syn and LV-Atg7 showed no reduction in levels of ?
Gene_expression (syn) of Atg7
17) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.09 Pain Relevance 0

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