INT296850

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 4.41
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Atg7) neurological system process (Atg7) cellular amino acid metabolic process (Atg7)
cytoplasm (Atg7)
Anatomy Link Frequency
brains 4
hippocampus 2
Atg7 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 48 99.84 Very High Very High Very High
Hippocampus 40 98.84 Very High Very High Very High
Limbic system 24 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
Locus ceruleus 8 5.00 Very Low Very Low Very Low
Neurobehavioral 8 5.00 Very Low Very Low Very Low
Substantia nigra 8 5.00 Very Low Very Low Very Low
Immobilon 8 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 472 97.72 Very High Very High Very High
Targeted Disruption 80 97.20 Very High Very High Very High
Neurodegenerative Disease 72 96.24 Very High Very High Very High
Infection 40 93.32 High High
Disease 440 91.64 High High
Lewy Body Disease 48 75.00 Quite High
Dementia 72 56.76 Quite High
Gauchers Disease 24 5.00 Very Low Very Low Very Low
Death 24 5.00 Very Low Very Low Very Low
Pick Disease Of The Brain 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-syn tg mice treated with the LV-control (Figure 9A–D, G) delivery of LV-Atg7 resulted in increased expression in Atg7 in pyramidal neurons in the hippocampus and in areas adjacent to the injection track in the neocortex (Figure 9E–G).
Positive_regulation (increased) of Gene_expression (expression) of Atg7 in hippocampus associated with pyramidal cell and hippocampus
1) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.32 Pain Relevance 0.15
-syn tg mice, we sought to determine whether viral-mediated delivery of Atg7 might also promote ?
Positive_regulation (mediated) of Gene_expression (delivery) of Atg7
2) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.37 Pain Relevance 0.11
Overexpression of Atg7 in an In Vitro Model Reduces ?
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of Atg7
3) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0 Pain Relevance 0
The increased levels of mTor and reduced Atg7 levels suggest there may be altered activation of the autophagy pathway in the brains of DLB patients.
Positive_regulation (increased) of Gene_expression (levels) of Atg7 in brains associated with parkinson's disease
4) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.90 Pain Relevance 0.09
-syn tg mice, we sought to determine whether viral-mediated delivery of Atg7 might also promote ?
Positive_regulation (delivery) of Gene_expression (delivery) of Atg7
5) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.37 Pain Relevance 0.11
syn, co-expression of Atg7 also resulted in significant activation of autophagy (Figure 10D, E) and a reduction in ?
Positive_regulation (resulted) of Gene_expression (co-expression) of Atg7
6) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.09 Pain Relevance 0
The increased levels of mTor and reduced Atg7 levels suggest there may be altered activation of the autophagy pathway in the brains of DLB patients.
Positive_regulation (increased) of Gene_expression (levels) of Atg7 in brains associated with parkinson's disease
7) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.91 Pain Relevance 0.09
Intra-cerebral infusion of rapamycin, an inhibitor of mTor, or injection of a lentiviral vector expressing Atg7 resulted in reduced accumulation of ?
Positive_regulation (resulted) of Gene_expression (injection) of Atg7
8) Confidence 0.35 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2824828 Disease Relevance 1.44 Pain Relevance 0

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