INT296852

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Context Info
Confidence 0.47
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 4.67
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Atg7) neurological system process (Atg7) cellular amino acid metabolic process (Atg7)
cytoplasm (Atg7)
Anatomy Link Frequency
neurons 2
brains 2
Atg7 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 30 90.52 High High
Hippocampus 25 77.20 Quite High
imagery 5 22.36 Low Low
Limbic system 15 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Locus ceruleus 5 5.00 Very Low Very Low Very Low
Neurobehavioral 5 5.00 Very Low Very Low Very Low
Substantia nigra 5 5.00 Very Low Very Low Very Low
Immobilon 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 295 99.84 Very High Very High Very High
Disease 275 98.96 Very High Very High Very High
Targeted Disruption 50 98.08 Very High Very High Very High
Neurodegenerative Disease 45 93.68 High High
Aging 10 93.44 High High
Movement Disorders 10 92.92 High High
Dementia 45 92.00 High High
Lewy Body Disease 30 80.32 Quite High
Infection 25 21.84 Low Low
Gauchers Disease 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In DLB cases, levels of Atg7 were moderately reduced compared to controls and AD cases (Figure 1A, D).
Negative_regulation (reduced) of Gene_expression (levels) of Atg7 associated with parkinson's disease and disease
1) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.77 Pain Relevance 0
The increased levels of mTor and reduced Atg7 levels suggest there may be altered activation of the autophagy pathway in the brains of DLB patients.
Negative_regulation (reduced) of Gene_expression (levels) of Atg7 in brains associated with parkinson's disease
2) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.90 Pain Relevance 0.09
-syn tg mice levels of mTor were elevated and Atg7 expression was reduced. mTor and LC3 was co-localized with neurons displaying ?
Negative_regulation (reduced) of Gene_expression (expression) of Atg7 in neurons
3) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 1.17 Pain Relevance 0
Since in addition to the increase in mTor, we also observed a reduction in Atg7 levels in DLB and ?
Negative_regulation (reduction) of Gene_expression (levels) of Atg7 associated with parkinson's disease
4) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.38 Pain Relevance 0.10
Intra-cerebral infusion of rapamycin, an inhibitor of mTor, or injection of a lentiviral vector expressing Atg7 resulted in reduced accumulation of ?
Negative_regulation (inhibitor) of Gene_expression (injection) of Atg7
5) Confidence 0.30 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2824828 Disease Relevance 1.45 Pain Relevance 0

General Comments

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