INT296853

Context Info Confidence 0.37 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 1.45 Pain Relevance 0.18

transport (Atg7) neurological system process (Atg7) cellular amino acid metabolic process (Atg7) cytoplasm (Atg7)

Anatomy Link Frequency neurons 1 brains 1 Atg7 (Mus musculus)

Pain Link Frequency Relevance Heat Pyramidal cell 18 90.92 Hippocampus 15 66.08 Limbic system 9 5.00 Substantia nigra 4 5.00 anesthesia 3 5.00 Locus ceruleus 3 5.00 Neurobehavioral 3 5.00 Immobilon 3 5.00 imagery 3 5.00 carbamazepine 1 5.00

Disease Link Frequency Relevance Heat Parkinson's Disease 186 96.40 Disease 180 91.64 Apoptosis 5 80.48 Targeted Disruption 34 79.76 Neurodegenerative Disease 43 60.72 Lewy Body Disease 18 50.00 Communicable Diseases 1 37.52 Cancer 4 36.68 Infection 16 32.48 Starvation 9 31.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The increased levels of mTor and reduced Atg7 levels suggest there may be altered activation of the autophagy pathway in the brains of DLB patients.

Positive_regulation (increased) of Atg7 in brains associated with parkinson's disease

1) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.90 Pain Relevance 0.09

-syn accumulation in the LV-Atg7-treated animals ameliorated the structural damage to neurons of ?

Positive_regulation (accumulation) of Atg7 in neurons

2) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.05 Pain Relevance 0.09

In the first conjugation event, Atg12 is conjugated to Atg5 in a reaction that requires Atg7 (E1-like) and Atg10 (E2-like) [7].

Positive_regulation (requires) of Atg7

3) Confidence 0.23 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.08 Pain Relevance 0

Taken together, these results support the possibility that alterations in the autophagy pathway and more specifically in mTor and Atg7 are associated with accumulation of ?

Positive_regulation (alterations) of Atg7

4) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.41 Pain Relevance 0

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