INT296853

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Context Info
Confidence 0.37
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.45
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Atg7) neurological system process (Atg7) cellular amino acid metabolic process (Atg7)
cytoplasm (Atg7)
Anatomy Link Frequency
neurons 1
brains 1
Atg7 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 18 90.92 High High
Hippocampus 15 66.08 Quite High
Limbic system 9 5.00 Very Low Very Low Very Low
Substantia nigra 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Locus ceruleus 3 5.00 Very Low Very Low Very Low
Neurobehavioral 3 5.00 Very Low Very Low Very Low
Immobilon 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
carbamazepine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 186 96.40 Very High Very High Very High
Disease 180 91.64 High High
Apoptosis 5 80.48 Quite High
Targeted Disruption 34 79.76 Quite High
Neurodegenerative Disease 43 60.72 Quite High
Lewy Body Disease 18 50.00 Quite Low
Communicable Diseases 1 37.52 Quite Low
Cancer 4 36.68 Quite Low
Infection 16 32.48 Quite Low
Starvation 9 31.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increased levels of mTor and reduced Atg7 levels suggest there may be altered activation of the autophagy pathway in the brains of DLB patients.
Positive_regulation (increased) of Atg7 in brains associated with parkinson's disease
1) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.90 Pain Relevance 0.09
-syn accumulation in the LV-Atg7-treated animals ameliorated the structural damage to neurons of ?
Positive_regulation (accumulation) of Atg7 in neurons
2) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.05 Pain Relevance 0.09
In the first conjugation event, Atg12 is conjugated to Atg5 in a reaction that requires Atg7 (E1-like) and Atg10 (E2-like) [7].
Positive_regulation (requires) of Atg7
3) Confidence 0.23 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.08 Pain Relevance 0
Taken together, these results support the possibility that alterations in the autophagy pathway and more specifically in mTor and Atg7 are associated with accumulation of ?
Positive_regulation (alterations) of Atg7
4) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.41 Pain Relevance 0

General Comments

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