INT296911

Context Info Confidence 0.09 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 1.49 Pain Relevance 0

mitochondrion (Casq1) Golgi apparatus (Casq1) molecular_function (Casq1) response to stress (Casq1) cytoplasm (Casq1)

Casq1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat ischemia 8 5.00 tolerance 4 5.00 Glutamate 4 5.00 Inflammation 4 5.00 Morphine 4 5.00

Disease Link Frequency Relevance Heat Hypoxia 208 99.84 Stress 24 69.04 Apoptosis 100 66.96 Shock 4 55.44 Death 16 48.72 Myocardial Infarction 16 43.32 Injury 64 27.12 Cv Unclassified Under Development 8 5.00 B-cell Acute Lymphoblastic Leukemia 4 5.00 Repression 4 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our results showed increased expression of calsequestrin in hypoxia-reoxygenation condition (p < 0.05), but there was no significant change in response to exposure to thiopental.

Positive_regulation (increased) of Gene_expression (expression) of calsequestrin associated with hypoxia

1) Confidence 0.09 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.29 Pain Relevance 0

Considering that calsequestrin overexpression increases SR Ca2+ content by inhibition of RyRs,42 calsequestrin overexpression is also likely to contribute to intracellular Ca2+ overload.

Positive_regulation (overexpression) of Gene_expression (overexpression) of calsequestrin

2) Confidence 0.09 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.44 Pain Relevance 0

Considering that calsequestrin overexpression increases SR Ca2+ content by inhibition of RyRs,42 calsequestrin overexpression is also likely to contribute to intracellular Ca2+ overload.

Positive_regulation (overexpression) of Gene_expression (overexpression) of calsequestrin

3) Confidence 0.09 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.38 Pain Relevance 0

Considering that calsequestrin overexpression increases SR Ca2+ content by inhibition of RyRs,42 calsequestrin overexpression is also likely to contribute to intracellular Ca2+ overload.

Positive_regulation (increases) of Gene_expression (overexpression) of calsequestrin

4) Confidence 0.07 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.38 Pain Relevance 0

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