INT296916

Context Info Confidence 0.06 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.44 Pain Relevance 0

mitochondrion (Casq1) Golgi apparatus (Casq1) molecular_function (Casq1) response to stress (Casq1) cytoplasm (Casq1)

Casq1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat ischemia 2 5.00 tolerance 1 5.00 Glutamate 1 5.00 Inflammation 1 5.00 Morphine 1 5.00

Disease Link Frequency Relevance Heat Hypoxia 52 88.04 Stress 6 69.04 Apoptosis 25 66.96 Shock 1 55.44 Death 4 48.72 Myocardial Infarction 4 29.44 Injury 16 13.24 Cv Unclassified Under Development 2 5.00 B-cell Acute Lymphoblastic Leukemia 1 5.00 Repression 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Considering that calsequestrin overexpression increases SR Ca2+ content by inhibition of RyRs,42 calsequestrin overexpression is also likely to contribute to intracellular Ca2+ overload.

Negative_regulation (inhibition) of Gene_expression (overexpression) of calsequestrin

1) Confidence 0.06 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.44 Pain Relevance 0

General Comments

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