INT296919

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.28
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Slc8a1) plasma membrane (Slc8a1) transmembrane transport (Slc8a1)
response to stress (Slc8a1)
Anatomy Link Frequency
cardiomyocytes 1
heart 1
Slc8a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 4 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Morphine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 104 99.00 Very High Very High Very High
Myocardial Infarction 8 95.74 Very High Very High Very High
Injury 32 75.28 Quite High
Apoptosis 50 71.52 Quite High
Lymphatic System Cancer 2 43.88 Quite Low
B-cell Acute Lymphoblastic Leukemia 2 43.52 Quite Low
Stress 12 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 4 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Ca2+ entry across the membrane through L-type Ca2+ channels is balanced by the efflux of Ca2+ from the cell via the NCX and PMCA1.36 In the present results, the density of L-type Ca2+ channels and PMCA1 appeared to decrease, but the quantification of NCX was higher in hypoxia-reoxygenated cells, similar to the observations in various animal models of heart failure.38,39 In a study using mice with cardiac-specific ablation of NCX, Ca2+ entry via reverse-mode NCX is a major cause of intracellular Ca2+ overload.40 When hypoxia-reoxygenated cells were treated with thiopental, transcription levels of PMCA1 and NCX were restored to the level of normal cells, but there was no alteration in the level of L-type Ca2+ channel.
Transcription (transcription) of NCX in heart associated with hypoxia and myocardial infarction
1) Confidence 0.24 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.58 Pain Relevance 0
However, mRNA levels of Na+-Ca2+ exchanger (NCX) and calsequestrin increased in hypoxia-reoxygenated cardiomyocytes.
Transcription (levels) of NCX in cardiomyocytes associated with hypoxia
2) Confidence 0.24 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.71 Pain Relevance 0

General Comments

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