INT29693

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Context Info
Confidence 0.31
First Reported 1988
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 11
Total Number 17
Disease Relevance 13.27
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

immune system process (Ahr) cell morphogenesis (Ahr) DNA binding (Ahr)
response to stress (Ahr) cytoplasm (Ahr) signal transducer activity (Ahr)
Anatomy Link Frequency
MCF-7 1
bronchus 1
Ahr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 52 99.48 Very High Very High Very High
antagonist 49 99.16 Very High Very High Very High
agonist 31 98.44 Very High Very High Very High
anesthesia 1 90.36 High High
fibrosis 15 75.44 Quite High
Morphine 1 58.24 Quite High
alcohol 4 56.00 Quite High
Potency 45 22.04 Low Low
Bioavailability 39 9.76 Low Low
dexamethasone 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 7 99.82 Very High Very High Very High
Breast Cancer 14 99.68 Very High Very High Very High
INFLAMMATION 52 99.48 Very High Very High Very High
Respiratory Syncytial Virus 818 99.32 Very High Very High Very High
Dyspnea 18 99.32 Very High Very High Very High
Cough 940 99.28 Very High Very High Very High
Asthma 383 98.20 Very High Very High Very High
Occupational Lung Diseases 15 96.28 Very High Very High Very High
Foreign Bodies 14 94.60 High High
Hepatotoxicity 2 89.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this case, it is suggested that asthma-like symptoms were due to localized airflow limitation in the right bronchus as well as to AHR associated with diffuse airway neutrophilic inflammation.
AHR Binding (associated) of in bronchus associated with asthma and inflammation
1) Confidence 0.31 Published 2001 Journal Respiration Section Abstract Doc Link 11223741 Disease Relevance 0.88 Pain Relevance 0.18
Asymptomatic AHR is believed to be associated with airway inflammation and remodeling (4, 5).
AHR Binding (associated) of associated with inflammation
2) Confidence 0.21 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526529 Disease Relevance 1.23 Pain Relevance 0.18
Another study showed that AHR to hypertonic saline is significantly associated with wheeze and dyspnoea but not associated with dry cough or nocturnal cough once confounders were accounted for [96].
AHR Binding (associated) of associated with cough and dyspnea
3) Confidence 0.17 Published 2005 Journal Cough Section Body Doc Link PMC1277009 Disease Relevance 1.11 Pain Relevance 0
Twelve subjects with asymptomatic AHR had a provocative concentration of methacholine causing a 20% fall in forced expiratory volume in one second (PC20) of ?
AHR Binding (asymptomatic) of
4) Confidence 0.17 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526529 Disease Relevance 1.60 Pain Relevance 0
Laprise et al. found that asymptomatic AHR is associated with airway inflammation and remodeling, but did not subanalyze data with respect to atopic status (4).
AHR Binding (associated) of associated with inflammation
5) Confidence 0.16 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526529 Disease Relevance 1.28 Pain Relevance 0.13
RSV derivatives displaying different affinity toward ER and AhR are shown in TableĀ 1 and further described in de Medina et al. [26].
AhR Binding (affinity) of associated with respiratory syncytial virus
6) Confidence 0.14 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.72 Pain Relevance 0
Although these observations stress a close relation between the AhR, which is known to be a target for RSV analogues, and NF-?
AhR Binding (known) of associated with stress and respiratory syncytial virus
7) Confidence 0.14 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.71 Pain Relevance 0.11
The AhR ligand was shown to directly inhibit NF-?
AhR Binding (ligand) of
8) Confidence 0.14 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.60 Pain Relevance 0.06
B acts as a common transcriptional factor for both RANKL and AhR-mediated signaling.
AhR Binding (factor) of
9) Confidence 0.14 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.53 Pain Relevance 0.05
Although these observations stress a close relation between the AhR, which is known to be a target for RSV analogues, and NF-?
AhR Binding (relation) of associated with stress and respiratory syncytial virus
10) Confidence 0.14 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.66 Pain Relevance 0.11
RSV analogues used in the study displayed different binding affinities to AhR and acted either as antagonists or as agonists.
AhR Binding (affinities) of associated with antagonist, agonist and respiratory syncytial virus
11) Confidence 0.14 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.66 Pain Relevance 0.29
In relation to RSV analogues as AhR ligands, it is of interest to mention that NFATc1 was reported to be activated upon the engagement of AhR in the breast cancer cell line MCF-7 [40].
AhR Binding (engagement) of in MCF-7 associated with breast cancer and respiratory syncytial virus
12) Confidence 0.14 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.50 Pain Relevance 0
The only RCT that examined the utility of AHR and response to inhaled salbutamol and ICS [47] found that the presence of AHR could not predict the efficacy of these therapies for cough [47].
AHR Binding (presence) of associated with cough
13) Confidence 0.13 Published 2005 Journal Cough Section Body Doc Link PMC1277009 Disease Relevance 1.23 Pain Relevance 0
The older studies that equated presence of AHR in children with cough as representative of asthma were not placebo-controlled studies, confounders were not adjusted for, or used unconventional definitions of AHR [97-100].
AHR Binding (presence) of associated with asthma and cough
14) Confidence 0.11 Published 2005 Journal Cough Section Body Doc Link PMC1277009 Disease Relevance 1.14 Pain Relevance 0.03
However, 1-benzylimidazole failed to bind with high affinity to the cytosolic Ah receptor.
cytosolic Ah receptor Neg (failed) Binding (bind) of
15) Confidence 0.10 Published 1988 Journal Biochem. Pharmacol. Section Abstract Doc Link 2840913 Disease Relevance 0.08 Pain Relevance 0.09
Noncoplanar PCBs, which contain chlorine in one or more of the four ortho positions, are poor ligands for the Ah receptor.
Ah receptor Binding (ligands) of
16) Confidence 0.07 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1277862 Disease Relevance 0.15 Pain Relevance 0
Coplanar PCBs lack ortho substitution, bind with high affinity to the Ah receptor, and mediate many of their effects through changes in gene expression initiated by binding to this receptor.
Ah receptor Neg (lack) Binding (bind) of
17) Confidence 0.07 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1277862 Disease Relevance 0.17 Pain Relevance 0

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