INT296945

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.13
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ADIPOQ, TNF) extracellular region (ADIPOQ, TNF) signal transduction (TNF)
generation of precursor metabolites and energy (ADIPOQ) endoplasmic reticulum (ADIPOQ) plasma membrane (TNF)
Anatomy Link Frequency
adipose tissue 1
ADIPOQ (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 9 99.66 Very High Very High Very High
Inflammation 14 98.74 Very High Very High Very High
cytokine 1 87.76 High High
fibrosis 8 67.76 Quite High
imagery 6 39.88 Quite Low
Inflammatory marker 1 35.68 Quite Low
abdominal pain 6 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
spinal inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 5 100.00 Very High Very High Very High
INFLAMMATION 15 98.74 Very High Very High Very High
Necrosis 1 86.12 High High
Cancer 1 85.76 High High
Fibrosis 10 74.88 Quite High
Peritoneal Panniculitis 29 70.40 Quite High
Disease Progression 1 67.60 Quite High
Panniculitis 2 66.84 Quite High
Calcification 1 59.24 Quite High
Increased Venous Pressure Under Development 2 56.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used methotrexate because of the evidence of ongoing chronic inflammation and in part the reported role of methotrexate in ameliorating adiponectin which may thus inhibit the migration of macrophages to the mesenteric adipose tissue and suppress local TNF-?
adiponectin Negative_regulation (suppress) of TNF in adipose tissue associated with inflammation, obesity and methotrexate
1) Confidence 0.03 Published 2010 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2825191 Disease Relevance 1.13 Pain Relevance 0.40

General Comments

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