INT29695

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Context Info
Confidence 0.15
First Reported 1988
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.56
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cyp2c22)
Anatomy Link Frequency
liver 2
Cyp2c22 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 4 99.50 Very High Very High Very High
Paracetamol 9 99.40 Very High Very High Very High
Taxol 6 99.10 Very High Very High Very High
Morphine 1 33.36 Quite Low
alcohol 1 32.24 Quite Low
Disease Link Frequency Relevance Heat
Toxicity 6 98.84 Very High Very High Very High
Hepatomegaly 1 81.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of 1-benzylimidazole on cytochromes P-450 induction and on the activities of epoxide hydrolases and UDP-glucuronosyltransferases in rat liver.
Regulation (Effect) of Positive_regulation (induction) of cytochromes P-450 in liver
1) Confidence 0.15 Published 1988 Journal Biochem. Pharmacol. Section Title Doc Link 2840913 Disease Relevance 0.08 Pain Relevance 0
These results demonstrate that Taxol, like dexamethasone, induces CYP3A and that increases in this P450 are responsible for increased acetaminophen toxicity.
Regulation (responsible) of Positive_regulation (increases) of P450 associated with toxicity, paracetamol, dexamethasone and taxol
2) Confidence 0.01 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9007036 Disease Relevance 0.48 Pain Relevance 1.14

General Comments

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