INT296963

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.17
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESRRA) nucleus (ESRRA) DNA binding (ESRRA)
Anatomy Link Frequency
3T3-L1 1
ESRRA (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 11 93.56 High High
Angina 2 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
behavioral therapy 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 127 98.76 Very High Very High Very High
Cv Unclassified Under Development 7 93.56 High High
Diabetes Mellitus 48 89.72 High High
Coronary Artery Disease 4 77.92 Quite High
Targeted Disruption 9 65.36 Quite High
Syndrome 15 60.56 Quite High
Disease 5 6.96 Low Low
Death 3 5.00 Very Low Very Low Very Low
Heart Disease 2 5.00 Very Low Very Low Very Low
Weight Loss 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In 3T3-L1 adipocytes, the effects of RIP140 on glucose uptake are at least partly mediated via the transcription factor Estrogen-related receptor alpha (ERR?)
Positive_regulation (mediated) of Estrogen-related receptor alpha in 3T3-L1 associated with obesity
1) Confidence 0.33 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.65 Pain Relevance 0
54,642 G>A promoter polymorphism: The more common (in Caucasians) PPARA G promoter is more responsive to ERR, while the variant A promoter is less effective at binding ERR and is therefore resistant to ERR-mediated transcription.
Positive_regulation (responsive) of ERR
2) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2933242 Disease Relevance 0.52 Pain Relevance 0.09

General Comments

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