INT296969

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Context Info
Confidence 0.78
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 29
Disease Relevance 26.23
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (NRIP1)
Anatomy Link Frequency
adipocytes 4
visceral 2
liver 2
muscle 2
reproductive organs 1
NRIP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 29 77.36 Quite High
behavioral therapy 29 39.24 Quite Low
anesthesia 29 29.32 Quite Low
Disease Link Frequency Relevance Heat
Obesity 3625 99.92 Very High Very High Very High
Targeted Disruption 261 99.50 Very High Very High Very High
Weight Loss 58 99.24 Very High Very High Very High
Death 29 83.76 Quite High
Impaired Glucose Tolerance 29 77.36 Quite High
Body Weight 29 75.76 Quite High
Thinness 29 69.60 Quite High
Hyperinsulinism 29 66.32 Quite High
Gallstones 29 24.08 Low Low
Disease 29 23.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We therefore searched the GEO profiles database http://www.ncbi.nlm.nih.gov/ for RIP140 mRNA expression in the human transcriptome.
Gene_expression (expression) of RIP140 mRNA
1) Confidence 0.78 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.90 Pain Relevance 0.04
Expression of RIP140 mRNA in subcutaneous WAT increased 2.5-fold after long term weight-loss to a weight-stable, lean state (cohort 2, P < 0.01) (Figure 1B).
Gene_expression (Expression) of RIP140 mRNA associated with obesity
2) Confidence 0.78 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.03 Pain Relevance 0
According to record GDS596 RIP140 mRNA is widely expressed in different human tissues with particularly high expression levels observed in lung, skeletal muscle, reproductive organs and brain.
Gene_expression (expressed) of RIP140 mRNA in reproductive organs
3) Confidence 0.78 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.95 Pain Relevance 0.03
RIP140 protein was detected by western blot analysis in subcutaneous WAT with preadipocytes as a negative control (Figure 3).


Gene_expression (detected) of RIP140 protein associated with obesity
4) Confidence 0.78 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.03 Pain Relevance 0
There was no difference in RIP140 mRNA expression between genders before (women 0.11 ± 0.34 vs. men 0.09 ± 0.13 log10 AU) or after (women 0.42 ± 0.10 vs. men 0.30 ± 0.12 log10 AU) weight-loss.
Gene_expression (expression) of RIP140 mRNA
5) Confidence 0.78 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.08 Pain Relevance 0
RIP140 mRNA expression was increased almost twofold in isolated adipocytes compared to corresponding intact pieces of WAT (P < 0.001) (Figure 2A).
Gene_expression (expression) of RIP140 mRNA in adipocytes associated with obesity
6) Confidence 0.78 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.18 Pain Relevance 0
However, the function and expression of RIP140 mRNA in human subcutaneous WAT, which comprises the main store of body fat, has to our knowledge not been reported.
Gene_expression (expression) of RIP140 mRNA in fat associated with obesity
7) Confidence 0.78 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.01 Pain Relevance 0.03
Preadipocytes were used as a negative control since RIP140 expression is induced in later stages of differentiation.
Gene_expression (expression) of RIP140
8) Confidence 0.78 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.05 Pain Relevance 0
RIP140 protein was detected in subcutaneous WAT from five women (age 32 ± 4 years; BMI 24 ± 8 kg/m2).
Gene_expression (detected) of RIP140 protein associated with obesity
9) Confidence 0.78 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.93 Pain Relevance 0
Surprisingly few studies have examined the expression of RIP140 expression in human organs.
Spec (examined) Gene_expression (expression) of RIP140
10) Confidence 0.78 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.97 Pain Relevance 0.04
For RIP140 detection the blot was blocked for 1 h at room temperature in Tris-buffered saline with 0.1% Tween-20 (TBS-T) and 3% BSA (SIGMA).
Gene_expression (detection) of RIP140
11) Confidence 0.67 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0 Pain Relevance 0
RIP140 mRNA and protein in WAT
Gene_expression (protein) of RIP140 mRNA associated with obesity
12) Confidence 0.67 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.27 Pain Relevance 0
Surprisingly few studies have examined the expression of RIP140 expression in human organs.
Gene_expression (expression) of RIP140
13) Confidence 0.60 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.96 Pain Relevance 0.04
In humans, RIP140 is lower expressed in visceral white adipose tissue (WAT) of obese versus lean subjects.
Gene_expression (expressed) of RIP140 in WAT associated with obesity
14) Confidence 0.60 Published 2010 Journal BMC Endocr Disord Section Abstract Doc Link PMC2825205 Disease Relevance 0.91 Pain Relevance 0
To accomplish this we investigated if RIP140 was present in human white fat cells and related the expression of RIP140 in human subcutaneous WAT to adiposity.
Gene_expression (expression) of RIP140 in white fat cells associated with obesity
15) Confidence 0.60 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.28 Pain Relevance 0
Furthermore, increased RIP140 expression in lean and after weight reduction may be a mechanism to economize on energy stores.
Gene_expression (expression) of RIP140 associated with weight loss
16) Confidence 0.60 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.56 Pain Relevance 0
In order to mimic the effect of gene knock out in mice we silenced RIP140 expression in human in vitro differentiated adipocytes and analyzed the effects of decreased mRNA levels of RIP140 on glucose transport and a set of genes involved in the control of energy homeostasis.


Gene_expression (expression) of RIP140 in adipocytes associated with targeted disruption and obesity
17) Confidence 0.60 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.29 Pain Relevance 0
Levels of RIP140 mRNA were lower in visceral as compared to subcutaneous WAT, and this was due to a difference in lean subjects only (Figure 1A).
Gene_expression (Levels) of RIP140 mRNA in visceral associated with obesity
18) Confidence 0.60 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.04 Pain Relevance 0
We have shown that RIP140 mRNA levels in subcutaneous WAT, as has previously been reported for visceral WAT [6], are inversely correlated with measures of adiposity and are enriched in fat cells of adipose tissue.
Gene_expression (levels) of RIP140 mRNA in visceral associated with obesity
19) Confidence 0.60 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.03 Pain Relevance 0
Receptor-interacting protein 140 (RIP140) is a nuclear receptor corepressor that in mice is expressed in several organs; however the mRNA levels in white adipose tissue (WAT) are higher than in other metabolically active tissues, such as brown adipose tissue (BAT), muscle, and liver [3-5].
Gene_expression (expressed) of Receptor-interacting protein 140 in muscle associated with obesity
20) Confidence 0.60 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.77 Pain Relevance 0.03

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