INT296981

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Context Info
Confidence 0.47
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.96
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (UCP1) small molecule metabolic process (UCP1) transmembrane transport (UCP1)
UCP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
behavioral therapy 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 500 99.84 Very High Very High Very High
Targeted Disruption 36 99.30 Very High Very High Very High
Hyperinsulinism 4 56.44 Quite High
Weight Loss 8 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 4 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Thinness 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Gallstones 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
UCP-1 encodes a member of the mitochondrial proton carrier family of proteins and is expressed in BAT, but only to a limited extent in WAT [22].
Gene_expression (expressed) of UCP-1 associated with obesity
1) Confidence 0.47 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.92 Pain Relevance 0
Elevated UCP-1 levels are thought to convert WAT towards a browner phenotype by allowing mitochondrial respiration to occur in the absence of ATP-synthesis with dissipation of the produced energy as heat.
Gene_expression (levels) of UCP-1 associated with obesity
2) Confidence 0.41 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.88 Pain Relevance 0
Moreover, RIP140 reduce basal glucose transport and expression of the genes GLUT4 and UCP-1.
Gene_expression (expression) of UCP-1
3) Confidence 0.37 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.04 Pain Relevance 0
RIP140 knock down increases glucose uptake and expression of UCP-1 and GLUT4
Gene_expression (expression) of UCP-1 associated with targeted disruption
4) Confidence 0.37 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.12 Pain Relevance 0

General Comments

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