INT296984

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 5.95
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (UCP1) small molecule metabolic process (UCP1) transmembrane transport (UCP1)
Anatomy Link Frequency
adipocytes 3
UCP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 7 92.00 High High
anesthesia 7 5.00 Very Low Very Low Very Low
behavioral therapy 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 875 99.84 Very High Very High Very High
Targeted Disruption 63 99.68 Very High Very High Very High
Death 7 99.20 Very High Very High Very High
Hyperinsulinism 7 97.64 Very High Very High Very High
Impaired Glucose Tolerance 7 92.00 High High
Body Weight 7 79.52 Quite High
Weight Loss 14 9.44 Low Low
Thinness 7 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Gallstones 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the cellular level several genes, including cell death-inducing DFFA-like effector a (CIDEA), uncoupling protein-1 (UCP-1), and glucose transporter 4 (GLUT4) are upregulated in adipocytes from RIPKO as compared to WT-mice.
Positive_regulation (upregulated) of UCP-1 in adipocytes associated with obesity and death
1) Confidence 0.42 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.01 Pain Relevance 0.05
At the cellular level several genes, including cell death-inducing DFFA-like effector a (CIDEA), uncoupling protein-1 (UCP-1), and glucose transporter 4 (GLUT4) are upregulated in adipocytes from RIPKO as compared to WT-mice.
Positive_regulation (upregulated) of uncoupling protein-1 in adipocytes associated with obesity and death
2) Confidence 0.37 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.02 Pain Relevance 0.05
This together with the elevated levels of UCP-1 suggests that RIP140 influences the function of existing mitochondria rather than biogenesis.
Positive_regulation (elevated) of UCP-1
3) Confidence 0.28 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.66 Pain Relevance 0
Elevated UCP-1 levels are thought to convert WAT towards a browner phenotype by allowing mitochondrial respiration to occur in the absence of ATP-synthesis with dissipation of the produced energy as heat.
Positive_regulation (Elevated) of UCP-1 associated with obesity
4) Confidence 0.28 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.88 Pain Relevance 0
RIP140 silencing in human in vitro differentiated adipocytes led to increased mRNA levels of UCP-1, but not PGC-1?
Positive_regulation (increased) of UCP-1 in adipocytes associated with obesity
5) Confidence 0.28 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.61 Pain Relevance 0
RIP140 silencing significantly increased mRNA levels of GLUT4 and UCP-1 compared to control cells (P < 0.01 for both) (Figure 4C).
Positive_regulation (increased) of UCP-1
6) Confidence 0.28 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.58 Pain Relevance 0
Knock down of RIP140 increased basal glucose transport and mRNA levels of glucose transporter 4 and uncoupling protein-1.


Positive_regulation (increased) of uncoupling protein-1 associated with targeted disruption
7) Confidence 0.25 Published 2010 Journal BMC Endocr Disord Section Abstract Doc Link PMC2825205 Disease Relevance 1.19 Pain Relevance 0

General Comments

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