INT296990

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.89
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MLST8) cytoplasm (MLST8)
Anatomy Link Frequency
WAT 1
MLST8 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 48 96.56 Very High Very High Very High
dexamethasone 2 39.68 Quite Low
Central nervous system 2 17.80 Low Low
Peripheral nervous system 2 7.80 Low Low
Potency 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
lidocaine 2 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
behavioral therapy 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 401 100.00 Very High Very High Very High
Targeted Disruption 11 82.08 Quite High
Cancer 10 50.00 Quite Low
Repression 2 29.60 Quite Low
Diabetes Mellitus 20 5.00 Very Low Very Low Very Low
Liver Cancer 6 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Retinoblastoma 2 5.00 Very Low Very Low Very Low
Insulin Resistance 2 5.00 Very Low Very Low Very Low
Weight Loss 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only one other study has addressed this question, using Zucker fatty rats that lack proper leptin signaling and therefore become extremely obese: Tusc5 mRNA and protein levels were very slightly increased in subcutaneous WAT, unchanged in mesenteric, and yet decreased substantially in epididymal WAT [4].
Positive_regulation (increased) of WAT associated with obesity
1) Confidence 0.05 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.96 Pain Relevance 0.04
-TUSC5 interactions, Tusc5 mRNA levels were compared in archived human WAT biopsy samples before and after treatment with the PPAR?
Positive_regulation (samples) of WAT associated with obesity
2) Confidence 0.04 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.67 Pain Relevance 0.08
RIP140 mRNA levels in subcutaneous WAT were decreased among obese compared to lean women and increased by weight-loss, but did not associate with mitochondrial DNA copy number.
Positive_regulation (increased) of WAT in WAT associated with obesity
3) Confidence 0.03 Published 2010 Journal BMC Endocr Disord Section Abstract Doc Link PMC2825205 Disease Relevance 1.25 Pain Relevance 0

General Comments

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