INT296996

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Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 15
Disease Relevance 14.18
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (NRIP1)
Anatomy Link Frequency
adipose tissue 4
adipocytes 4
visceral 2
NRIP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 15 61.00 Quite High
anesthesia 15 5.00 Very Low Very Low Very Low
behavioral therapy 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 1875 100.00 Very High Very High Very High
Targeted Disruption 135 97.70 Very High Very High Very High
Thinness 15 77.92 Quite High
Weight Loss 30 76.48 Quite High
Death 15 67.40 Quite High
Impaired Glucose Tolerance 15 61.00 Quite High
Body Weight 15 48.52 Quite Low
Hyperinsulinism 15 45.60 Quite Low
Gallstones 15 32.40 Quite Low
Disease 15 31.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also confirmed decreased levels (25%) of RIP140 mRNA in visceral WAT of obese subjects (cohort 1, P < 0.01) (Figure 1A).
Negative_regulation (decreased) of RIP140 mRNA in visceral associated with obesity
1) Confidence 0.59 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.15 Pain Relevance 0
It has recently been reported that RIP140 mRNA and protein levels are decreased in visceral WAT of morbidly obese as compared to lean humans implying that human RIP140 may, just as its rodent orthologue, regulate adipose tissue metabolism [6].
Negative_regulation (decreased) of RIP140 mRNA in adipose tissue associated with obesity
2) Confidence 0.59 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.85 Pain Relevance 0.03
Thus, our results support the notion that inhibition of human RIP140, similar to the murine homologue, increases the expression of genes involved in the regulation of energy expenditure.
Negative_regulation (inhibition) of RIP140
3) Confidence 0.59 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.72 Pain Relevance 0
RIP140 mRNA levels were decreased approximately 50% in obese compared to lean women in subcutaneous WAT (cohort 1, P < 0.001) (Figure 1A).
Negative_regulation (decreased) of RIP140 mRNA associated with obesity
4) Confidence 0.59 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.11 Pain Relevance 0
Furthermore, obesity was associated with reduced levels of RIP140 mRNA in adipocytes (obese N = 5, 0.87 ± 0.12 log10 AU vs. lean N = 5, 1.12 ± 0.10 log10 AU, P > 0.01).
Negative_regulation (reduced) of RIP140 mRNA in adipocytes associated with obesity
5) Confidence 0.59 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.18 Pain Relevance 0
In order to mimic the effect of gene knock out in mice we silenced RIP140 expression in human in vitro differentiated adipocytes and analyzed the effects of decreased mRNA levels of RIP140 on glucose transport and a set of genes involved in the control of energy homeostasis.


Negative_regulation (decreased) of RIP140 in adipocytes associated with targeted disruption and obesity
6) Confidence 0.43 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.33 Pain Relevance 0
On the other hand, down regulation of RIP140 in obesity could be accompanied by changes in expression of other transcription factors and co-factors, which could lead to a different metabolic outcome than down regulation of RIP140 in cell cultures.


Negative_regulation (regulation) of RIP140 associated with obesity
7) Confidence 0.43 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.56 Pain Relevance 0
Mice lacking Receptor-interacting protein 140 (RIP140) have reduced body fat which at least partly is mediated through increased lipid and glucose metabolism in adipose tissue.
Negative_regulation (lacking) of Receptor-interacting protein 140 in adipose tissue associated with obesity
8) Confidence 0.43 Published 2010 Journal BMC Endocr Disord Section Abstract Doc Link PMC2825205 Disease Relevance 0.70 Pain Relevance 0
Depletion of RIP140 mRNA levels was confirmed by real-time PCR to be significantly knocked down by ~80% (p < 0.01) (Figure 4A).
Negative_regulation (Depletion) of RIP140 mRNA
9) Confidence 0.43 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.05 Pain Relevance 0
In 3T3-L1 adipocytes, inhibition of RIP140 by siRNA has been reported to increase insulin-stimulated glucose uptake [5].
Negative_regulation (inhibition) of RIP140 in adipocytes associated with obesity
10) Confidence 0.43 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.04 Pain Relevance 0
Mice lacking Receptor-interacting protein 140 (RIP140) have reduced body fat which at least partly is mediated through increased lipid and glucose metabolism in adipose tissue.
Negative_regulation (lacking) of RIP140 in adipose tissue associated with obesity
11) Confidence 0.43 Published 2010 Journal BMC Endocr Disord Section Abstract Doc Link PMC2825205 Disease Relevance 0.71 Pain Relevance 0
Considering the functions ascribed to lack of RIP140 in in vitro studies, i.e. increased glucose uptake and elevated energy expenditure, it is difficult to link reduced RIP140 levels in obesity with a primary role in adiposity.
Negative_regulation (reduced) of RIP140 associated with obesity
12) Confidence 0.43 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.64 Pain Relevance 0
Furthermore, obesity was associated with reduced levels of RIP140 mRNA in adipocytes (obese N = 5, 0.87 ± 0.12 log10 AU vs. lean N = 5, 1.12 ± 0.10 log10 AU, P > 0.01).
Negative_regulation (levels) of RIP140 mRNA in adipocytes associated with obesity
13) Confidence 0.43 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.18 Pain Relevance 0
RIP140 mRNA levels in subcutaneous WAT were decreased among obese compared to lean women and increased by weight-loss, but did not associate with mitochondrial DNA copy number.
Negative_regulation (decreased) of RIP140 mRNA in WAT associated with obesity
14) Confidence 0.43 Published 2010 Journal BMC Endocr Disord Section Abstract Doc Link PMC2825205 Disease Relevance 1.25 Pain Relevance 0
As has previously been reported in visceral WAT [6], abdominal subcutaneous RIP140 mRNA levels were reduced in obesity.
Negative_regulation (reduced) of RIP140 mRNA in visceral associated with obesity
15) Confidence 0.43 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.72 Pain Relevance 0

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