INT296997

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Context Info
Confidence 0.70
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 5.77
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (NRIP1)
Anatomy Link Frequency
adipocytes 6
NRIP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 7 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
behavioral therapy 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 875 100.00 Very High Very High Very High
Weight Loss 14 99.24 Very High Very High Very High
Targeted Disruption 63 90.24 High High
Hyperinsulinism 7 46.16 Quite Low
Impaired Glucose Tolerance 7 5.00 Very Low Very Low Very Low
Body Weight 7 5.00 Very Low Very Low Very Low
Thinness 7 5.00 Very Low Very Low Very Low
Death 7 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Gallstones 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RIP140 mRNA expression was increased almost twofold in isolated adipocytes compared to corresponding intact pieces of WAT (P < 0.001) (Figure 2A).
Positive_regulation (increased) of Gene_expression (expression) of RIP140 mRNA in adipocytes associated with obesity
1) Confidence 0.70 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.24 Pain Relevance 0
Preadipocytes were used as a negative control since RIP140 expression is induced in later stages of differentiation.
Positive_regulation (induced) of Gene_expression (expression) of RIP140
2) Confidence 0.70 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.05 Pain Relevance 0
Expression of RIP140 mRNA in subcutaneous WAT increased 2.5-fold after long term weight-loss to a weight-stable, lean state (cohort 2, P < 0.01) (Figure 1B).
Positive_regulation (increased) of Gene_expression (Expression) of RIP140 mRNA associated with obesity
3) Confidence 0.50 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.04 Pain Relevance 0
RIP140 expression increased during adipocyte differentiation in vitro and was higher in isolated adipocytes compared to corresponding pieces of WAT.
Positive_regulation (increased) of Gene_expression (expression) of RIP140 in adipocytes associated with obesity
4) Confidence 0.47 Published 2010 Journal BMC Endocr Disord Section Abstract Doc Link PMC2825205 Disease Relevance 1.23 Pain Relevance 0
Furthermore, increased RIP140 expression in lean and after weight reduction may be a mechanism to economize on energy stores.
Positive_regulation (increased) of Gene_expression (expression) of RIP140 associated with weight loss
5) Confidence 0.47 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.56 Pain Relevance 0
We therefore consider the alternative that the physiological role of increased levels of RIP140 in lean subjects functions to economize on energy stores more likely.
Positive_regulation (increased) of Gene_expression (levels) of RIP140
6) Confidence 0.47 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.63 Pain Relevance 0
Furthermore, human RIP140 mRNA expression increased during adipocyte differentiation, which is in agreement with results in mice [3-5,18].
Positive_regulation (increased) of Gene_expression (expression) of RIP140 mRNA in adipocyte
7) Confidence 0.47 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.02 Pain Relevance 0

General Comments

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