INT297020

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Context Info
Confidence 0.36
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.38
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CLTC) mitosis (CLTC) mitochondrion (CLTC)
vesicle-mediated transport (CLTC) structural molecule activity (CLTC) plasma membrane (CLTC)
Anatomy Link Frequency
eye 1
blood 1
neurons 1
CLTC (Homo sapiens)
Pain Link Frequency Relevance Heat
reflex sympathetic dystrophy 4 92.16 High High
Pain 16 76.40 Quite High
cva 12 64.08 Quite High
Central nervous system 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
intrathecal 4 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 10 99.16 Very High Very High Very High
Rupture 32 98.66 Very High Very High Very High
Infection 170 98.52 Very High Very High Very High
Nervous System Injury 6 96.52 Very High Very High Very High
Hypersensitivity 14 94.68 High High
Complex Regional Pain Syndromes 4 92.16 High High
Disease 246 89.48 High High
Dizziness 2 79.12 Quite High
Pain 16 76.40 Quite High
Adhesions 4 73.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Monoclonal antibodies specific for the cellular proteins, CLTC (Sigma Aldrich), AP2B1 (Abcam), DNM2 (Sigma Aldrich), ARRB1 (Abnova), ATP6V0A1 (Sigma Aldrich) and ARPC1B (Santa Cruz Biotechnology) were used for Western detection.
Positive_regulation (used) of CLTC
1) Confidence 0.36 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.08 Pain Relevance 0
With regard to biochemical or immunological response to the CHC, baseline blood results were compared with samples from 30 and 90 days posttreatment: ?
Positive_regulation (response) of CHC in blood
2) Confidence 0.32 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2988615 Disease Relevance 1.45 Pain Relevance 0.41
Each cord was stressed to failure, ie, until cord rupture was achieved, with a curvilinear trend being demonstrated between increasing CHC dose and decreasing stress required to achieve cord rupture – 89% of the trend was directly attributable (following regression analysis) to the CHC dose administered.
Positive_regulation (increasing) of CHC associated with stress and rupture
3) Confidence 0.29 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2988615 Disease Relevance 0.97 Pain Relevance 0
It can be observed that at least one of the four siRNAs directed against each specific gene (CLTC, AP2B1, DNM2, ARRB1, ATP6V0A1 and ARPC1B) can result in more than 50% inhibition of DENV infection (Figure 3G) hence indicating the specificity of these genes in mediating DENV infection.
Positive_regulation (result) of CLTC associated with infection
4) Confidence 0.17 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.81 Pain Relevance 0
In situ hybridization was not able to shed light as to where the elevated MHCI-HC transcript levels are localized, in neurons receiving afferents from the intact or from the enucleated eye.
Positive_regulation (elevated) of MHCI-HC in neurons
5) Confidence 0.05 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
We used immunohistochemistry to localize the elevated MHCI-HC levels to neurons receiving afferent inputs from the intact eye.
Positive_regulation (elevated) of MHCI-HC in eye
6) Confidence 0.05 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0.07 Pain Relevance 0

General Comments

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