INT29704

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Context Info
Confidence 0.56
First Reported 1988
Last Reported 2010
Negated 15
Speculated 9
Reported most in Body
Documents 51
Total Number 60
Disease Relevance 22.13
Pain Relevance 22.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleolus (Casp3) nucleus (Casp3) intracellular (Casp3)
Anatomy Link Frequency
NAc 4
apoptotic cell 3
hepatocytes 2
spinal cord 1
brain 1
Casp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 113 100.00 Very High Very High Very High
Dopamine 110 100.00 Very High Very High Very High
Eae 34 100.00 Very High Very High Very High
antidepressant 26 100.00 Very High Very High Very High
withdrawal 16 100.00 Very High Very High Very High
lidocaine 10 100.00 Very High Very High Very High
Glutamate 1595 99.98 Very High Very High Very High
Nucleus accumbens 88 99.98 Very High Very High Very High
Hippocampus 49 99.82 Very High Very High Very High
opiate 20 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 1085 100.00 Very High Very High Very High
Death 899 99.58 Very High Very High Very High
Neuroblastoma 4 98.94 Very High Very High Very High
Glioma 6 98.58 Very High Very High Very High
Neurodegenerative Disease 88 97.42 Very High Very High Very High
Drug Dependence 13 96.68 Very High Very High Very High
Stress 113 96.12 Very High Very High Very High
Inflammatory Pain 11 96.08 Very High Very High Very High
Anxiety Disorder 14 95.52 Very High Very High Very High
Cv Unclassified Under Development 44 95.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the expression pattern and regulation of TNFR1a, TRADD, and the executioner protease, Caspase 3, indicate that the extrinsic pathway to apoptosis [43] is active in RGCs undergoing IONT or IONC.
Regulation (regulation) of Caspase 3 associated with apoptosis
1) Confidence 0.56 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 0.98 Pain Relevance 0.06
Clonidine treatment had no evident effects on caspase-3 mRNA level and DNA fragmentation in the cortex of an 8-day-old rat.
Neg (no) Spec (evident) Regulation (effects) of caspase-3 mRNA in cortex associated with clonidine
2) Confidence 0.54 Published 2004 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 15351510 Disease Relevance 0.18 Pain Relevance 0.90
Exposure to glutamate up-regulated caspase-3 protein levels while caspase inhibitors blocked this apoptotic process.
Regulation (regulated) of caspase-3 associated with glutamate and apoptosis
3) Confidence 0.49 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 0.88 Pain Relevance 0.32
In littermate wild-type rats, the injured centrilobular hepatocytes were positive for TUNEL staining and featured elevated expre ssion of cleaved caspase-3 and Cx43, which is not expressed in normal hepatocytes.
Regulation (positive) of caspase-3 in hepatocytes
4) Confidence 0.44 Published 2010 Journal Toxicol Pathol Section Abstract Doc Link 20097795 Disease Relevance 0.75 Pain Relevance 0.54
However, we saw no difference between CPP and CPA rats in any brain region examined.
Neg (no) Regulation (difference) of CPP in CPA
5) Confidence 0.39 Published 2008 Journal Behav. Neurosci. Section Abstract Doc Link 18823165 Disease Relevance 0 Pain Relevance 0.59
The effects of mirtazapine, a noradrenergic and specific serotonergic antidepressant, on morphine withdrawal and morphine conditioned place preference (CPP) were investigated in rats.
Spec (investigated) Regulation (effects) of CPP associated with antidepressant, withdrawal and morphine
6) Confidence 0.39 Published 2008 Journal Am J Drug Alcohol Abuse Section Abstract Doc Link 18618337 Disease Relevance 0.07 Pain Relevance 0.75
Although these observations strongly indicate that caspase-3 is essential for apoptosis in mammalian cells, the mechanisms involved in caspase-3 regulation of the neuronal system remain to be elucidated.
Regulation (regulation) of caspase-3 in neuronal associated with apoptosis
7) Confidence 0.36 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 1.04 Pain Relevance 0.03
Our studies show that up-regulation of caspase-3 expression preceded neuronal cell death, supporting the possibility that glutamate-induced apoptotic cell death was the consequence of up-regulation of caspase-3 gene in cortical neurons.
Regulation (regulation) of caspase-3 in apoptotic cell associated with glutamate, apoptosis and death
8) Confidence 0.36 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 0.98 Pain Relevance 0.21
The results (Figure 12) indicate that glutamate treatment for 3 h, did not significantly change the levels of caspase-3 active form.
Neg (not) Regulation (change) of caspase-3 associated with glutamate
9) Confidence 0.36 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 0.21 Pain Relevance 0.43
The kinetics of glutamate effects on caspase-3 protein levels indicate that a significant increase in the levels occurred by 3 h of glutamate (5 mM) exposure and reached maximum levels observed at 6 h (54% increase) (Figure 7).
Regulation (effects) of caspase-3 associated with glutamate
10) Confidence 0.36 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 0.42 Pain Relevance 0.38
The results show that morphine-induced maintenance of CPP was not affected by pretreatment with any CRFR antagonists.
Neg (not) Regulation (affected) of CPP associated with antagonist and morphine
11) Confidence 0.34 Published 2000 Journal Neuroreport Section Abstract Doc Link 10943688 Disease Relevance 0.32 Pain Relevance 0.74
Interestingly, OBX did not enhance LDH levels, whereas it prompted changes in caspase-3 activity, data which indicate that OBX may be induced cell damage.
Regulation (changes) of caspase-3
12) Confidence 0.34 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2518376 Disease Relevance 0.39 Pain Relevance 0.06
Intra-NAc core infusion of SCH 39166 (12.5, 25, and 50 ng/1 microl per side) did not affect the acquisition of morphine-induced CPP, while L-sulpiride (12.5, 25, and 50 ng/1 microl per side) impaired CPP acquisition only at the dose of 50 ng/1 microl per side.
Neg (not) Regulation (affect) of CPP in NAc
13) Confidence 0.33 Published 2006 Journal Psychopharmacology (Berl.) Section Body Doc Link 16724186 Disease Relevance 0.06 Pain Relevance 0
Changes in BDNF and caspase-3 after HI
Regulation (Changes) of caspase-3
14) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000320 Disease Relevance 0.15 Pain Relevance 0.05
Caspase-3 immunoreactivity was evaluated in the lumbar spinal cord at the end of the gas exposure (n = 3 per group).
Regulation (immunoreactivity) of Caspase-3 in spinal cord
15) Confidence 0.27 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18499598 Disease Relevance 0 Pain Relevance 0
Western blot analysis showed time-dependent changes of caspase-3 and IL-1beta protein in the cervical cord and gastric antrum of rats with cervical spondylosis; there was no significant expression of caspase-3 and IL-1beta protein in the control group at 3 mo and 5 mo after the sham operation, whereas there was a significant difference in caspase-3 and IL-1beta protein levels between the model group rats followed up for 3 mo and those for 5 mo (P < 0.05).
Regulation (changes) of caspase-3 in gastric antrum
16) Confidence 0.27 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 17552004 Disease Relevance 0 Pain Relevance 0
In conclusion, morphine pretreatment delivered as a constant infusion can have pronounced and long-lasting effects on DA release and CPP, which may have important implications for drug-seeking behavior and treatment of substance abuse disorders.
Regulation (effects) of CPP associated with dopamine, drug abuse and morphine
17) Confidence 0.27 Published 2004 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 14751461 Disease Relevance 0.10 Pain Relevance 1.51
Therefore, it seems likely that the absence of caspase-7 upregulation is a consequence of the regulation of caspase-3.
Regulation (regulation) of caspase-3
18) Confidence 0.27 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.75 Pain Relevance 0.17
Morphological differences between these animals, such as dark cell change, caspase-3 and APP immunoreactivity, were also investigated.
Regulation (immunoreactivity) of caspase-3
19) Confidence 0.26 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17362936 Disease Relevance 1.03 Pain Relevance 0.11
The ED(50) values of MK212, mCPP, and TFMPP were 39.2, 119.9, and 191.9 microg, respectively.
Regulation (values) of mCPP
20) Confidence 0.26 Published 2004 Journal Pain Section Abstract Doc Link 15109520 Disease Relevance 0.28 Pain Relevance 0.79

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