INT297043

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.22
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (AP2B1) cytosol (AP2B1) vesicle-mediated transport (AP2B1)
plasma membrane (AP2B1)
AP2B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 168 99.08 Very High Very High Very High
Targeted Disruption 8 96.96 Very High Very High Very High
Dengue 22 50.00 Quite Low
Dengue Hemorrhagic Fever 18 5.00 Very Low Very Low Very Low
Fever 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Viral Meningitis 6 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Myalgia 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reverse-transfection of Huh 7 cells with siRNAs targeting CLTC, AP2B1, DNM2, ARRB1, ATP6V0A1 and ARPC1B showed dosage dependent reductions in the levels of the respective proteins when compared to the levels in the mock-transfected cells (Figure 3).
Regulation (targeting) of AP2B1
1) Confidence 0.19 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.50 Pain Relevance 0
The knock-down of ATP6V0A1 and CLTC (at concentration of 50 nM) produced the strongest inhibition of DENV infection. siRNA smart pool-based deconvolution assays targeting CLTC, AP2B1, DNM2, ARRB1, ATP6V0A1 and ARPC1B were also performed to ensure that inhibitory effects on DENV infection observed in the primary screen was specific and not due to off-target gene effects of the siRNA primary screen. 30 nM of each specific individual siRNA of the smart pool (4 specific siRNAs) directed against each of the respective genes were reverse transfected into RD cells and subsequently subjected to DENV infection.
Regulation (targeting) of AP2B1 associated with targeted disruption and infection
2) Confidence 0.19 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.72 Pain Relevance 0

General Comments

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