INT29705

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Context Info
Confidence 0.48
First Reported 1988
Last Reported 2010
Negated 7
Speculated 5
Reported most in Abstract
Documents 13
Total Number 18
Disease Relevance 5.37
Pain Relevance 10.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleolus (Casp3) nucleus (Casp3) intracellular (Casp3)
Anatomy Link Frequency
nucleus accumbens 4
hepatocytes 2
olfactory bulbs 2
Casp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 80 100.00 Very High Very High Very High
Eae 16 99.84 Very High Very High Very High
Nucleus accumbens 8 99.74 Very High Very High Very High
Glutamate 289 99.60 Very High Very High Very High
aspirin 5 98.88 Very High Very High Very High
antagonist 14 98.76 Very High Very High Very High
Hippocampus 10 97.60 Very High Very High Very High
Endocannabinoid 3 96.28 Very High Very High Very High
Intracerebroventricular 1 96.16 Very High Very High Very High
agonist 7 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 18 99.88 Very High Very High Very High
Stomach Cancer 5 99.58 Very High Very High Very High
Cancer 8 98.48 Very High Very High Very High
Stress 27 96.72 Very High Very High Very High
Anxiety Disorder 4 95.52 Very High Very High Very High
Death 199 95.36 Very High Very High Very High
Optic Nerve Injuries 34 94.32 High High
Apoptosis 212 94.04 High High
Targeted Disruption 1 93.96 High High
Hepatotoxicity 4 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bilateral intra-accumbal administration of AM251 (5, 25 and 125 ng/0.5 microl per side) dose-dependently reduced the acquisition and expression of morphine-induced CPP in morphine-sensitized rats, while bilateral intra-accumbal administration of neither saline nor DMSO (0.5 microl/side) had effects on the acquisition and expression of morphine-induced CPP in sensitized rats.
Regulation (effects) of Positive_regulation (induced) of CPP associated with morphine
1) Confidence 0.48 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 18773925 Disease Relevance 0 Pain Relevance 1.57
In littermate wild-type rats, the injured centrilobular hepatocytes were positive for TUNEL staining and featured elevated expre ssion of cleaved caspase-3 and Cx43, which is not expressed in normal hepatocytes.
Regulation (positive) of Positive_regulation (cleaved) of caspase-3 in hepatocytes
2) Confidence 0.44 Published 2010 Journal Toxicol Pathol Section Abstract Doc Link 20097795 Disease Relevance 0.75 Pain Relevance 0.54
In addition, we measured active Casp3 to know whether its upregulation was followed by its activation.
Spec (whether) Regulation (followed) of Spec (whether) Positive_regulation (upregulation) of Casp3
3) Confidence 0.36 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 0.84 Pain Relevance 0
Removal of olfactory bulbs in rats did not affect LDH activity (Figure 2), whereas caspase-3 activity was significantly enhanced (0.26 ± 0.004 OD arbitrary units/mg protein in control group vs 0.37 ± 0.004 OD arbitrary units/mg protein in OBX group, p < 0.001) (Figure 2).
Neg (not) Regulation (affect) of Positive_regulation (enhanced) of caspase-3 in olfactory bulbs
4) Confidence 0.34 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2518376 Disease Relevance 0.31 Pain Relevance 0.03
To examine the effect of aripiprazole on the expression of morphine-induced CPP, rats received aripiprazole (0, 0.03, 0.1,and 0.3 mg/kg, i.p.) 30 min before testing for the expression of CPP.
Spec (examine) Regulation (effect) of Positive_regulation (induced) of CPP associated with morphine
5) Confidence 0.24 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19353810 Disease Relevance 0.18 Pain Relevance 0.76
To examine the effect of aripiprazole on reinstatement of morphine-induced CPP, rats received aripiprazole 30 min before testing for reinstatement of CPP.
Spec (examine) Regulation (effect) of Positive_regulation (induced) of CPP associated with morphine
6) Confidence 0.24 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19353810 Disease Relevance 0.21 Pain Relevance 0.98
Aripiprazole significantly decreased the reinstatement of CPP induced by a priming injection of morphine but had no effect on the expression of morphine-induced CPP or locomotor activity.
Neg (no) Regulation (effect) of Positive_regulation (induced) of CPP associated with eae and morphine
7) Confidence 0.24 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19353810 Disease Relevance 0.21 Pain Relevance 0.95
Thus, the 5,7-dihydroxytryptamine lesions of the nucleus accumbens differently influenced the CPP induced by the drugs studied and, with the exception of diazepam, the various behavioural effects elicited by each drug.
Regulation (influenced) of Positive_regulation (induced) of CPP in nucleus accumbens associated with nucleus accumbens
8) Confidence 0.24 Published 1988 Journal Behav. Brain Res. Section Abstract Doc Link 2840924 Disease Relevance 0.10 Pain Relevance 0.74
Thus, 1 to 5 mM glutamate increased caspase-3 protein levels by 45 to 66% respectively, however, higher concentrations of glutamate (10–20 mM) did not result in any further increase in caspase-3 protein levels (Figure 6).
Neg (not) Regulation (result) of Positive_regulation (increase) of caspase-3 associated with glutamate
9) Confidence 0.22 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC555946 Disease Relevance 0.42 Pain Relevance 0.36
Effect of estrogens on the activation of calpain and caspase-3
Regulation (Effect) of Positive_regulation (activation) of caspase-3
10) Confidence 0.21 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1526740 Disease Relevance 0.62 Pain Relevance 0.15
Sulpiride (0.3, 1.0 and 3.0 microg/rat), but not L-arginine (0.3, 1.0 and 3.0 microg/rat) or L-NAME (0.3, 1.0 and 3.0 microg/rat), in combination with morphine (5.0 mg/kg), during conditioning, significantly altered morphine-induced CPP.
Neg (not) Regulation (altered) of Neg (not) Positive_regulation (induced) of CPP associated with morphine
11) Confidence 0.21 Published 2003 Journal Brain Res. Section Abstract Doc Link 12763619 Disease Relevance 0 Pain Relevance 0.68
To investigate the influence of VPA on morphine-induced CPP, rats received chronic pretreatment of i.c.v.
Spec (investigate) Regulation (influence) of Positive_regulation (induced) of CPP associated with morphine
12) Confidence 0.21 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17904288 Disease Relevance 0 Pain Relevance 0.82
However, agents did not alter morphine-induced CPP.
Neg (not) Regulation (alter) of Neg (not) Positive_regulation (induced) of CPP associated with morphine
13) Confidence 0.20 Published 2007 Journal Brain Res. Section Abstract Doc Link 17631872 Disease Relevance 0 Pain Relevance 1.11
No effect on morphine-induced CPP was observed when the DA antagonists were infused into the NAc shell or core 10 min before the test session.
Neg (No) Regulation (effect) of Positive_regulation (induced) of CPP in NAc
14) Confidence 0.20 Published 2006 Journal Psychopharmacology (Berl.) Section Body Doc Link 16724186 Disease Relevance 0.06 Pain Relevance 0
The results show that morphine-induced maintenance of CPP was not affected by pretreatment with any CRFR antagonists.
Neg (not) Regulation (affected) of Positive_regulation (maintenance) of CPP associated with antagonist and morphine
15) Confidence 0.15 Published 2000 Journal Neuroreport Section Abstract Doc Link 10943688 Disease Relevance 0.32 Pain Relevance 0.74
The present study was performed to examine the effect of 100 Hz peripheral electric stimulation (PES) on the expression of morphine-induced CPP.
Spec (examine) Regulation (effect) of Positive_regulation (induced) of CPP associated with morphine
16) Confidence 0.11 Published 2003 Journal Brain Res. Section Abstract Doc Link 12885422 Disease Relevance 0 Pain Relevance 0.71
CONCLUSIONS: Activation and upregulation of caspase-3 or caspase-8 protein were responsible for Indomethacin-induced K562 cell apoptosis.
Regulation (responsible) of Positive_regulation (upregulation) of caspase-3
17) Confidence 0.07 Published 2004 Journal Chin. Med. J. Section Body Doc Link 15265368 Disease Relevance 0 Pain Relevance 0
Our results suggest that one of the major pathways which mediates the anti-tumour response of aspirin and indomethacin in gastric cancer cells is through up-regulation of bax and bak and activation of caspase-3.
Regulation (regulation) of Positive_regulation (activation) of caspase-3 associated with aspirin, cancer and stomach cancer
18) Confidence 0.05 Published 2001 Journal Carcinogenesis Section Abstract Doc Link 11532860 Disease Relevance 1.35 Pain Relevance 0.32

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