INT29708

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Context Info
Confidence 0.78
First Reported 1988
Last Reported 2010
Negated 4
Speculated 9
Reported most in Abstract
Documents 177
Total Number 186
Disease Relevance 56.36
Pain Relevance 77.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) endoplasmic reticulum (Gria1) plasma membrane (Gria1)
protein complex (Gria1)
Anatomy Link Frequency
hippocampus 17
dorsal horn 16
retina 8
neurons 8
spinal cord 5
Gria1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 3613 100.00 Very High Very High Very High
antagonist 1210 100.00 Very High Very High Very High
Glutamate 1116 100.00 Very High Very High Very High
Glutamate receptor 838 100.00 Very High Very High Very High
agonist 351 100.00 Very High Very High Very High
gABA 58 100.00 Very High Very High Very High
Inflammation 640 99.98 Very High Very High Very High
Antinociceptive 6 99.96 Very High Very High Very High
Hippocampus 2243 99.84 Very High Very High Very High
Spinal cord 491 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cold Sores 20 100.00 Very High Very High Very High
INFLAMMATION 627 99.98 Very High Very High Very High
Aging 2865 99.96 Very High Very High Very High
Autism 547 99.84 Very High Very High Very High
Herpes Simplex Virus 11 99.84 Very High Very High Very High
Diabetes Mellitus 1131 99.74 Very High Very High Very High
Stress 148 99.72 Very High Very High Very High
Pressure And Volume Under Development 4 99.72 Very High Very High Very High
Anxiety Disorder 1401 99.44 Very High Very High Very High
Disease 236 99.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant changes in DRG glutamate receptor expression were seen for alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid, kainite, and N-methyl-D aspartate receptors.
Gene_expression (expression) of DRG glutamate receptor in DRG
1) Confidence 0.78 Published 2005 Journal Spine Section Body Doc Link 15770173 Disease Relevance 0 Pain Relevance 0
Western blots and immunohistochemistry were performed to examine the expression and localization of GluR1 and the phosphorylated forms of GluR1 (phospho-GluR1) at Ser-831 and Ser-845 with specific antibodies.
Spec (examine) Gene_expression (expression) of GluR1
2) Confidence 0.78 Published 2003 Journal Neuroscience Section Abstract Doc Link 14596864 Disease Relevance 0.09 Pain Relevance 0.39
Here, we used herpes simplex virus vectors to examine how transient increases in the expression of GluR1 or GluR2 protein in the shell component of NAc affect the rewarding impact of electrical stimulation of the medial forebrain bundle, as reflected by intracranial self-stimulation (ICSS) thresholds in rats.
Gene_expression (expression) of GluR1 in NAc associated with nucleus accumbens and herpes simplex virus
3) Confidence 0.78 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17093088 Disease Relevance 0.10 Pain Relevance 0.36
For example, 94% of enkephalin-containing neurons, 75% of substance P-containing neurons, and 87% of enkephalin and substance P co-containing neurons expressed GluR1 messenger RNA.
Gene_expression (expressed) of GluR1 in neurons associated with enkephalin and substance p
4) Confidence 0.77 Published 1998 Journal Neuroscience Section Abstract Doc Link 9483559 Disease Relevance 0 Pain Relevance 0.66
To explore the possibility that GluR1 subunits may be synthesized by many striatal projection neurons, but selectively localized to their dendrites, we have used light-microscopic and electron-microscopic immunohistochemistry in combination with single-cell reverse transcription-polymerase chain reaction.
Gene_expression (synthesized) of GluR1 in dendrites associated with projection neuron
5) Confidence 0.77 Published 1998 Journal Neuroscience Section Abstract Doc Link 9483559 Disease Relevance 0 Pain Relevance 0.20
Kainate receptors expressing the GluR5 subunit of glutamate receptor are present at high levels on small diameter primary afferent neurones that are considered to mediate nociceptive inputs.
Gene_expression (expressing) of glutamate receptor associated with nociception and glutamate receptor
6) Confidence 0.77 Published 1998 Journal Neuropharmacology Section Abstract Doc Link 9849666 Disease Relevance 0.23 Pain Relevance 0.36
By method of Western blot, expression of GluR1 (the main subunit of the AMPA receptor) and its phosphorylated forms at serine 845 (pGluR1-Ser845) and at serine 831 (pGluR1-Ser831) in the spinal dorsal horn was observed.
Gene_expression (expression) of GluR1 in dorsal horn associated with spinal dorsal horn
7) Confidence 0.77 Published 2008 Journal Brain Res. Section Abstract Doc Link 18289517 Disease Relevance 0.76 Pain Relevance 0.78
These findings provide evidence for a specific decrease in GluR1 expression in the cord in response to joint inflammation.
Gene_expression (expression) of GluR1 in joint associated with inflammation and arthritis
8) Confidence 0.77 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8126556 Disease Relevance 0.31 Pain Relevance 0.37
One day after LPS injection, when joint swelling was maximal, GluR1 expression was bilaterally decreased by 25% in the substantia gelatinosa at the level of the lumbar cord.
Gene_expression (expression) of GluR1 in joint associated with substantia gelatinosa and pressure and volume under development
9) Confidence 0.77 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8126556 Disease Relevance 0.48 Pain Relevance 0.62
Glutamate receptor gene expression in spinal cord of arthritic rats.
Gene_expression (expression) of Glutamate receptor gene in spinal cord associated with glutamate receptor, arthritis and spinal cord
10) Confidence 0.77 Published 1994 Journal J. Neurosci. Section Title Doc Link 8126556 Disease Relevance 0.60 Pain Relevance 0.63
In control rats, GluR1 expression was prominent throughout the layers of the gray matter of the spinal cord.
Gene_expression (expression) of GluR1 in spinal cord associated with spinal cord
11) Confidence 0.77 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8126556 Disease Relevance 0.55 Pain Relevance 0.64
Microinjections of a herpes simplex virus (HSV) vector that causes local overexpression of GluR1 (HSV-GluR1) into the VTA can enhance the ability of morphine to establish conditioned place preferences, suggesting that altered GluR1 expression in this region is directly associated with changes in the rewarding efficacy of morphine.
Gene_expression (overexpression) of GluR1 associated with ventral tegmentum, cold sores, herpes simplex virus and morphine
12) Confidence 0.76 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684909 Disease Relevance 0.45 Pain Relevance 0.97
Repeated administration of morphine increases expression of GluR1 (an AMPA glutamate receptor subunit) in the ventral tegmental area (VTA) of the midbrain, an important neural substrate for the rewarding actions of morphine.
Gene_expression (expression) of GluR1 in neural associated with ventral tegmentum, glutamate receptor, midbrain and morphine
13) Confidence 0.76 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684909 Disease Relevance 0.38 Pain Relevance 0.76
Microinjections of a herpes simplex virus (HSV) vector that causes local overexpression of GluR1 (HSV-GluR1) into the VTA can enhance the ability of morphine to establish conditioned place preferences, suggesting that altered GluR1 expression in this region is directly associated with changes in the rewarding efficacy of morphine.
Gene_expression (expression) of GluR1 associated with ventral tegmentum, cold sores, herpes simplex virus and morphine
14) Confidence 0.76 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684909 Disease Relevance 0.51 Pain Relevance 1.05
In order to further elucidate this hypothesis, the aim of the present study was to determine whether these enkephalinoceptive neurons express GluR1 and GluR2/3 AMPA receptor subunits.
Spec (whether) Gene_expression (express) of GluR1 in neurons
15) Confidence 0.76 Published 1997 Journal Synapse Section Abstract Doc Link 9068124 Disease Relevance 0 Pain Relevance 0.25
Moreover, LTG significantly enhanced the surface expression of GluR1/2 AMPA receptor in a time- and dose-dependent manner in cultured hippocampal neurons [132].
Gene_expression (expression) of GluR1 in neurons associated with lamotrigine
16) Confidence 0.75 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.58 Pain Relevance 0.93
Our findings are consistent with others showing that, in vitro, BDNF upregulates local translation of PSD95 through mTOR pathway [76] and enhances the expression of GluR1 subunit of AMPA receptors via activation of mTOR [48].
Gene_expression (expression) of GluR1
17) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0.07 Pain Relevance 0.18
The main findings of the present study are: (1) a biphasic activation of hippocampal mTOR signaling is associated with IA training and is required for its memory formation; (2) activation of the mTOR cascade in the dorsal hippocampus is initiated by BDNF; (3) previously synthesized BDNF is rapidly released immediately after IA training whereas around 3 h after training, new synthesis of BDNF protein is needed for LTM formation; (4) learning related BDNF/mTOR cascade activation after training induces GluR1 expression in hippocampal synaptic plasma membranes; and (5) GluR1 translation during training or 3 h later is required for IA memory consolidation.
Gene_expression (expression) of GluR1 in plasma associated with hippocampus
18) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.05
In addition, we found that pre- or post-training administration of function-blocking anti-BDNF antibodies into dorsal CA1 hampered IA LTM retention, abolished the learning-induced biphasic activation of mTOR and its readout, p70S6K and blocked GluR1 expression, indicating that BDNF is an upstream factor controlling mTOR signaling during fear-memory consolidation.
Gene_expression (expression) of GluR1 in dorsal associated with anxiety disorder
19) Confidence 0.75 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2695538 Disease Relevance 0.10 Pain Relevance 0.04
Furthermore, it has been shown that dopaminergic stimulation of hippocampal neurons leads to a rapid increase in dendritic expression of GluR1 subunit through a mechanism that requires protein synthesis [77].
Gene_expression (expression) of GluR1 in neurons
20) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.03

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