INT29709

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Context Info
Confidence 0.69
First Reported 1988
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 36
Total Number 42
Disease Relevance 9.43
Pain Relevance 17.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) endoplasmic reticulum (Gria1) plasma membrane (Gria1)
protein complex (Gria1)
Anatomy Link Frequency
plasma 6
spinal cord 6
hippocampus 6
ventral 4
retina 2
Gria1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 115 100.00 Very High Very High Very High
Glutamate receptor 104 100.00 Very High Very High Very High
Morphine 36 99.98 Very High Very High Very High
Inflammation 57 99.96 Very High Very High Very High
tetrodotoxin 6 99.84 Very High Very High Very High
Ventral tegmentum 48 99.68 Very High Very High Very High
Rostral ventromedial medulla 5 99.68 Very High Very High Very High
Raphe magnus 3 99.62 Very High Very High Very High
Nucleus accumbens 12 99.60 Very High Very High Very High
long-term potentiation 205 99.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 47 99.98 Very High Very High Very High
INFLAMMATION 54 99.96 Very High Very High Very High
Cold Sores 8 99.92 Very High Very High Very High
Herpes Simplex Virus 5 99.36 Very High Very High Very High
Diabetes Mellitus 87 99.28 Very High Very High Very High
Anxiety Disorder 329 98.80 Very High Very High Very High
Depression 60 95.04 Very High Very High Very High
Nociception 13 92.84 High High
Shock 122 92.24 High High
Injury 5 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In control rats, GluR1 expression was prominent throughout the layers of the gray matter of the spinal cord.
Positive_regulation (prominent) of Gene_expression (expression) of GluR1 in spinal cord associated with spinal cord
1) Confidence 0.69 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8126556 Disease Relevance 0.55 Pain Relevance 0.65
Repeated administration of morphine increases expression of GluR1 (an AMPA glutamate receptor subunit) in the ventral tegmental area (VTA) of the midbrain, an important neural substrate for the rewarding actions of morphine.
Positive_regulation (increases) of Gene_expression (expression) of GluR1 in neural associated with ventral tegmentum, glutamate receptor, midbrain and morphine
2) Confidence 0.68 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684909 Disease Relevance 0.38 Pain Relevance 0.76
Therefore, we determined whether IA training increases the expression of GluR1 protein levels in the dorsal hippocampus.
Spec (whether) Positive_regulation (increases) of Gene_expression (expression) of GluR1 protein in hippocampus associated with hippocampus
3) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.19
Second, they demonstrate that one of the main effects of BDNF action during memory formation is to increase the expression of GluR1 in synaptic membranes, and that it does so by activating the translation machinery through the engagement of mTOR and its downstream target p70S6K.
Positive_regulation (increase) of Gene_expression (expression) of GluR1
4) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0.05 Pain Relevance 0.12
Furthermore, it has been shown that dopaminergic stimulation of hippocampal neurons leads to a rapid increase in dendritic expression of GluR1 subunit through a mechanism that requires protein synthesis [77].
Positive_regulation (increase) of Gene_expression (expression) of GluR1 in neurons
5) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.03
Although processes other than translation could be associated to the increase in GluR1 expression, so far, the regulation of protein synthesis has been the only mechanism in which mTOR has been implicated.
Positive_regulation (increase) of Gene_expression (expression) of GluR1
6) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.10
The main findings of the present study are: (1) a biphasic activation of hippocampal mTOR signaling is associated with IA training and is required for its memory formation; (2) activation of the mTOR cascade in the dorsal hippocampus is initiated by BDNF; (3) previously synthesized BDNF is rapidly released immediately after IA training whereas around 3 h after training, new synthesis of BDNF protein is needed for LTM formation; (4) learning related BDNF/mTOR cascade activation after training induces GluR1 expression in hippocampal synaptic plasma membranes; and (5) GluR1 translation during training or 3 h later is required for IA memory consolidation.
Positive_regulation (induces) of Gene_expression (expression) of GluR1 in plasma associated with hippocampus
7) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.05
Western blotting on tissue taken from the LA was performed to assay training-induced expression of GluR1, synapsin, and synaptophysin in the LA at each of the different time points.
Positive_regulation (induced) of Gene_expression (expression) of GluR1 associated with amygdala
8) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.70 Pain Relevance 0.18
Here, we used herpes simplex virus vectors to examine how transient increases in the expression of GluR1 or GluR2 protein in the shell component of NAc affect the rewarding impact of electrical stimulation of the medial forebrain bundle, as reflected by intracranial self-stimulation (ICSS) thresholds in rats.
Spec (examine) Positive_regulation (increases) of Gene_expression (expression) of GluR1 in NAc associated with nucleus accumbens and herpes simplex virus
9) Confidence 0.50 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17093088 Disease Relevance 0.10 Pain Relevance 0.36
Microinjections of a herpes simplex virus (HSV) vector that causes local overexpression of GluR1 (HSV-GluR1) into the VTA can enhance the ability of morphine to establish conditioned place preferences, suggesting that altered GluR1 expression in this region is directly associated with changes in the rewarding efficacy of morphine.
Positive_regulation (overexpression) of Gene_expression (overexpression) of GluR1 associated with ventral tegmentum, cold sores, herpes simplex virus and morphine
10) Confidence 0.49 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684909 Disease Relevance 0.45 Pain Relevance 0.97
45 after training abolished the increase in GluR1 expression occurring 3 h after training.
Positive_regulation (occurring) of Gene_expression (expression) of GluR1
11) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.24
45 after training abolished the increase in GluR1 expression occurring 3 h after training.
Positive_regulation (increase) of Gene_expression (expression) of GluR1
12) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.24
Drugs of abuse and stress increase the expression of GluR1 and NMDAR1 glutamate receptor subunits in the rat ventral tegmental area: common adaptations among cross-sensitizing agents.
Positive_regulation (increase) of Gene_expression (expression) of GluR1 in ventral associated with stress, ventral tegmentum and glutamate receptor
13) Confidence 0.45 Published 1996 Journal J. Neurosci. Section Title Doc Link 8613793 Disease Relevance 0.15 Pain Relevance 0.64
Extending previous findings [32], [33], we found that IA training resulted in an increase in the expression of GluR1 protein in a subcellular fraction enriched in synaptic plasma membranes (P2) isolated from the dorsal hippocampus 15 min or 3 h after training (Figure 6A, +75±9 percent respect to naïve animals p<0.001 n?
Positive_regulation (increase) of Gene_expression (expression) of GluR1 protein in plasma associated with hippocampus
14) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.21
Enhanced expression of metabotropic glutamate receptor 3 messenger RNA in the rat spinal cord during ultraviolet irradiation induced peripheral inflammation.
Positive_regulation (Enhanced) of Gene_expression (expression) of glutamate receptor in spinal cord associated with inflammation, glutamate receptor and spinal cord
15) Confidence 0.45 Published 1998 Journal Neuroscience Section Title Doc Link 9466463 Disease Relevance 0.57 Pain Relevance 0.83
In the present study, we show that auditory Pavlovian fear conditioning is associated with significant and persistent increases in the expression of the postsynaptically-localized protein GluR1 and the presynaptically-localized proteins synapsin and synaptophysin in the LA.
Positive_regulation (increases) of Gene_expression (expression) of GluR1 associated with anxiety disorder and amygdala
16) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.30 Pain Relevance 0.32
The main findings of the present study are: (1) a biphasic activation of hippocampal mTOR signaling is associated with IA training and is required for its memory formation; (2) activation of the mTOR cascade in the dorsal hippocampus is initiated by BDNF; (3) previously synthesized BDNF is rapidly released immediately after IA training whereas around 3 h after training, new synthesis of BDNF protein is needed for LTM formation; (4) learning related BDNF/mTOR cascade activation after training induces GluR1 expression in hippocampal synaptic plasma membranes; and (5) GluR1 translation during training or 3 h later is required for IA memory consolidation.
Positive_regulation (needed) of Gene_expression (translation) of GluR1 in plasma associated with hippocampus
17) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695538 Disease Relevance 0 Pain Relevance 0.05
Here we show that consolidation of inhibitory avoidance (IA) LTM entails mTOR activation in the dorsal hippocampus at the moment of and 3 h after training and is associated with a rapid and rapamycin-sensitive increase in AMPA receptor GluR1 subunit expression, which was also blocked by intra-hippocampal delivery of GluR1 antisense oligonucleotides (ASO).
Positive_regulation (increase) of Gene_expression (expression) of GluR1 in hippocampus associated with hippocampus
18) Confidence 0.42 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2695538 Disease Relevance 0.07 Pain Relevance 0.05
Repeated restraint stress also paradigm (2 stressors/d under variable conditions) increased both GluR1 and NMDAR1 levels in this brain region.
Positive_regulation (increased) of Gene_expression (levels) of GluR1 in brain associated with stress
19) Confidence 0.42 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8613793 Disease Relevance 0.43 Pain Relevance 1.13
GluR1 and GluR2 surface expression was also increased by tetrodotoxin alone or in combination with an N-methyl-d-aspartate receptor or AMPA receptor antagonist but not by the l-type Ca(2+) channel antagonist nifedipine.
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of GluR1 associated with tetrodotoxin and antagonist
20) Confidence 0.42 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19674091 Disease Relevance 0.07 Pain Relevance 0.65

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