INT2971

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Context Info
Confidence 0.61
First Reported 1976
Last Reported 2010
Negated 12
Speculated 2
Reported most in Body
Documents 42
Total Number 44
Disease Relevance 28.81
Pain Relevance 7.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma cells 2
eosinophils 2
body 2
mast cells 2
smooth muscle 1
IGHE (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 22 100.00 Very High Very High Very High
headache 12 100.00 Very High Very High Very High
Multiple sclerosis 5 100.00 Very High Very High Very High
cytokine 183 99.92 Very High Very High Very High
stellate ganglion block 8 99.88 Very High Very High Very High
aspirin 119 99.66 Very High Very High Very High
Inflammation 192 99.26 Very High Very High Very High
alcohol 30 97.88 Very High Very High Very High
Morphine 7 97.12 Very High Very High Very High
methadone 6 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Asthma 553 100.00 Very High Very High Very High
Hypersensitivity 275 100.00 Very High Very High Very High
Pancreatitis 23 100.00 Very High Very High Very High
Demyelinating Disease 7 100.00 Very High Very High Very High
Body Weight 6 100.00 Very High Very High Very High
Schistosomiasis 24 99.92 Very High Very High Very High
Infection 185 99.84 Very High Very High Very High
Disease 255 99.82 Very High Very High Very High
Ganglion Cysts 2 99.76 Very High Very High Very High
Alopecia Areata 3 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In isolated pollinosis no changes in any specific IgE levels were detectable.
Neg (no) Regulation (changes) of IgE
1) Confidence 0.61 Published 2003 Journal J Clin Anesth Section Body Doc Link 14698360 Disease Relevance 0 Pain Relevance 0
In a model including the factors that may affect the serum levels of IgE (namely, age, sex, cigarette smoking, parasites, and family and personal history of allergy), IgE levels were found to be significantly higher in the patients with unstable angina and acute myocardial infarction compared to the patients with stable angina pectoris and controls.
Regulation (affect) of IgE associated with stable angina pectoris, angina, nicotine addiction, hypersensitivity and myocardial infarction
2) Confidence 0.60 Published 1991 Journal Int. J. Cardiol. Section Abstract Doc Link 1869329 Disease Relevance 1.25 Pain Relevance 0.58
IgE plaque-forming cells and productive epsilon mRNA were not significantly affected by omalizumab treatment.
Neg (not) Regulation (affected) of IgE in plaque
3) Confidence 0.58 Published 2004 Journal Ann. Allergy Asthma Immunol. Section Body Doc Link 15478383 Disease Relevance 0.12 Pain Relevance 0
Several dermatological and inflammatory disorders have been associated with IgE dysregulation and elevated IgE levels.
Regulation (dysregulation) of IgE associated with inflammation
4) Confidence 0.55 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2837605 Disease Relevance 2.14 Pain Relevance 0.25
Several dermatological and inflammatory disorders have been associated with IgE dysregulation and elevated IgE levels.
Regulation (dysregulation) of IgE associated with inflammation
5) Confidence 0.55 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2837605 Disease Relevance 2.13 Pain Relevance 0.25
Serum levels of IgE, other immunoglobulins and complement (C's) in patients with multiple sclerosis in exacerbation and other neurologic diseases.
Regulation (levels) of IgE associated with multiple sclerosis and disease
6) Confidence 0.45 Published 1976 Journal Acta Neurol. Scand. Section Title Doc Link 1251679 Disease Relevance 0.94 Pain Relevance 0.27
Serum levels of IgE, other immunoglobulins and complement (C's) in patients with multiple sclerosis in exacerbation and other neurologic <span style="backgroun</span>d-color:#FFA07A">diseases.
Regulation (levels) of IgE associated with multiple sclerosis and disease
7) Confidence 0.45 Published 1976 Journal Acta Neurol. Scand. Section Title Doc Link 1251679 Disease Relevance 0.94 Pain Relevance 0.27
High total IgE titers were observed to affect specificity of the assays.


Regulation (affect) of IgE
8) Confidence 0.44 Published 2007 Journal Anesthesiology Section Body Doc Link 17667569 Disease Relevance 0 Pain Relevance 0
Results showed that the specificities of the IgE antibodies are directed towards quaternary or tertiary ammonium ions on the drugs that bind the antibodies.
Regulation (directed) of IgE
9) Confidence 0.44 Published 1985 Journal Ann Fr Anesth Reanim Section Abstract Doc Link 3159315 Disease Relevance 0.09 Pain Relevance 0.10
We used logistic and linear regression to analyse binary outcomes and log-transformed IgE, respectively, controlling for potential confounders.
Regulation (controlling) of IgE
10) Confidence 0.43 Published 2005 Journal Clin. Exp. Allergy Section Body Doc Link 15649261 Disease Relevance 0.07 Pain Relevance 0
Effects of omalizumab, a humanized monoclonal anti-IgE antibody, on nasal reactivity to allergen and local IgE synthesis.
Regulation (Effects) of IgE in nasal associated with headache
11) Confidence 0.42 Published 2004 Journal Ann. Allergy Asthma Immunol. Section Title Doc Link 15478383 Disease Relevance 0 Pain Relevance 0.10
Sera were analyzed retrospectively for IgE and histamine release (passive sensitization) to chlorhexidine.
Spec (analyzed) Regulation (retrospectively) of IgE
12) Confidence 0.40 Published 2007 Journal J. Allergy Clin. Immunol. Section Body Doc Link 17559915 Disease Relevance 0.08 Pain Relevance 0
Prediction methods based on artificial intelligence and machine learning have gained popularity due to the available data on IgE epitopes, amino acid descriptors and several
Regulation (data) of IgE associated with intellectual impairment
13) Confidence 0.39 Published 2008 Journal Bioinformation Section Body Doc Link PMC2258428 Disease Relevance 0.84 Pain Relevance 0.08
Considering clinical use, the dosage of omalizumab is established in a range from 150 mg every 4 weeks to 375 mg every 2 weeks; individual dosing depends on the body weight and the target level of total IgE, up to 700 IU/mL.
Regulation (depends) of IgE in body associated with body weight
14) Confidence 0.34 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727776 Disease Relevance 0.92 Pain Relevance 0
Th2 cytokines by regulating IgE class switching as well as inducing humoral immunity, would aggravate allergic respiratory disease.
Regulation (regulating) of IgE in respiratory associated with hypersensitivity, respiratory disease and cytokine
15) Confidence 0.30 Published 2008 Journal Clin Mol Allergy Section Body Doc Link PMC2377255 Disease Relevance 0.73 Pain Relevance 0.27
A specific inhibitor of aminopeptidase, amastatin, had no effect on anti-IgE induced tryptase and histamine release and was used as control.
Neg (no) Regulation (effect) of IgE
16) Confidence 0.29 Published 2004 Journal Asian Pac. J. Allergy Immunol. Section Abstract Doc Link 15783133 Disease Relevance 0 Pain Relevance 0.08
An apparent advantage of adding omalizumab to allergen immunotherapy is that anti-IgE treatment is not allergen specific and thus is effective also on symptoms induced by other allergens in polysensitized patients (Hamelman et al 2002).


Regulation (effective) of IgE
17) Confidence 0.29 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727776 Disease Relevance 0.44 Pain Relevance 0
These results suggested that in CU subjects their accompanying allergic diseases did not affect on IgE immune responses to staphylococcal superantigens.
Neg (not) Regulation (affect) of IgE associated with urticaria, hypersensitivity and disease
18) Confidence 0.28 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2580015 Disease Relevance 1.30 Pain Relevance 0.15
On that point, this study has some limitations that the atopic status of patients might affect on IgE sensitization to staphylococcal superantigens than the effect of aspirin sensitivity.
Spec (might) Regulation (affect) of IgE associated with aspirin
19) Confidence 0.28 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2580015 Disease Relevance 0.77 Pain Relevance 0.05
No change in serum free IgE was reported in the placebo groups.
Neg (No) Regulation (change) of IgE
20) Confidence 0.27 Published 2008 Journal Core Evidence Section Body Doc Link PMC2899803 Disease Relevance 0.15 Pain Relevance 0.07

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