INT29715

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Context Info
Confidence 0.43
First Reported 1986
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
hypothalamus 2
neurons 2
Crh (Rattus norvegicus)
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endogenous opioid 5 99.76 Very High Very High Very High
narcan 7 94.72 High High
opiate 4 82.72 Quite High
agonist 3 82.16 Quite High
Morphine 16 81.52 Quite High
nMDA receptor antagonist 2 81.20 Quite High
opioid receptor 4 75.00 Quite High
antagonist 1 74.24 Quite High
excitatory amino acid 1 66.24 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the sites of EOP and CRH inhibition may be located upstream of the site of NMDA stimulation on the GnRH neuronal pathway, and that CRH can inhibit LH secretion without mediation by EOP neurons.
CRH Negative_regulation (inhibit) of Localization (secretion) of LH in neurons
1) Confidence 0.43 Published 1997 Journal Neuroendocrinology Section Abstract Doc Link 9067992 Disease Relevance 0 Pain Relevance 0.41
Recent experiments have shown that corticotropin-releasing hormone (CRH) inhibits gonadotropin hormone-releasing hormone (GnRH) and luteinizing hormone (LH) release, and endogenous opioid peptides have been implicated in the mediation of these effects.
corticotropin-releasing hormone Negative_regulation (inhibits) of Localization (release) of LH associated with endogenous opioid
2) Confidence 0.41 Published 1988 Journal Brain Res. Section Abstract Doc Link 2841006 Disease Relevance 0 Pain Relevance 0.56
Recent experiments have shown that corticotropin-releasing hormone (CRH) inhibits gonadotropin hormone-releasing hormone (GnRH) and luteinizing hormone (LH) release, and endogenous opioid peptides have been implicated in the mediation of these effects.
CRH Negative_regulation (inhibits) of Localization (release) of LH associated with endogenous opioid
3) Confidence 0.41 Published 1988 Journal Brain Res. Section Abstract Doc Link 2841006 Disease Relevance 0 Pain Relevance 0.56
Together, these findings indicate that CRF inhibits LH secretion by inhibiting LHRH release from the hypothalamus, and that the latter action involves endogenous opioid peptides.
CRF Negative_regulation (inhibits) of Localization (secretion) of LH in hypothalamus associated with endogenous opioid
4) Confidence 0.32 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2963219 Disease Relevance 0 Pain Relevance 0.14
Corticotropin releasing factor (CRF) given i.c.v. at doses of 0.02-2 nmol, significantly inhibited luteinising hormone (LH) secretion in castrate male rats.
CRF Negative_regulation (inhibited) of Localization (secretion) of LH
5) Confidence 0.32 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2963219 Disease Relevance 0 Pain Relevance 0.10

General Comments

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