INT29716

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Context Info
Confidence 0.44
First Reported 1986
Last Reported 1988
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0
Pain Relevance 2.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh, Gnrh1) extracellular region (Crh, Gnrh1) molecular_function (Gnrh1)
response to stress (Crh) cytoplasm (Crh)
Crh (Rattus norvegicus)
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endogenous opioid 5 99.76 Very High Very High Very High
narcan 1 82.96 Quite High
opiate 8 82.72 Quite High
agonist 4 82.16 Quite High
Morphine 32 81.52 Quite High
opioid receptor 8 75.00 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent experiments have shown that corticotropin-releasing hormone (CRH) inhibits gonadotropin hormone-releasing hormone (GnRH) and luteinizing hormone (LH) release, and endogenous opioid peptides have been implicated in the mediation of these effects.
CRH Negative_regulation (inhibits) of Localization (release) of luteinizing hormone associated with endogenous opioid
1) Confidence 0.44 Published 1988 Journal Brain Res. Section Abstract Doc Link 2841006 Disease Relevance 0 Pain Relevance 0.56
Recent experiments have shown that corticotropin-releasing hormone (CRH) inhibits gonadotropin hormone-releasing hormone (GnRH) and luteinizing hormone (LH) release, and endogenous opioid peptides have been implicated in the mediation of these effects.
CRH Negative_regulation (inhibits) of Localization (release) of GnRH associated with endogenous opioid
2) Confidence 0.44 Published 1988 Journal Brain Res. Section Abstract Doc Link 2841006 Disease Relevance 0 Pain Relevance 0.56
Recent experiments have shown that corticotropin-releasing hormone (CRH) inhibits gonadotropin hormone-releasing hormone (GnRH) and luteinizing hormone (LH) release, and endogenous opioid peptides have been implicated in the mediation of these effects.
corticotropin-releasing hormone Negative_regulation (inhibits) of Localization (release) of GnRH associated with endogenous opioid
3) Confidence 0.44 Published 1988 Journal Brain Res. Section Abstract Doc Link 2841006 Disease Relevance 0 Pain Relevance 0.56
Recent experiments have shown that corticotropin-releasing hormone (CRH) inhibits gonadotropin hormone-releasing hormone (GnRH) and luteinizing hormone (LH) release, and endogenous opioid peptides have been implicated in the mediation of these effects.
corticotropin-releasing hormone Negative_regulation (inhibits) of Localization (release) of luteinizing hormone associated with endogenous opioid
4) Confidence 0.44 Published 1988 Journal Brain Res. Section Abstract Doc Link 2841006 Disease Relevance 0 Pain Relevance 0.56
Corticotropin releasing factor (CRF) given i.c.v. at doses of 0.02-2 nmol, significantly inhibited luteinising hormone (LH) secretion in castrate male rats.
CRF Negative_regulation (inhibited) of Localization (secretion) of luteinising hormone
5) Confidence 0.42 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2963219 Disease Relevance 0 Pain Relevance 0.10

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