INT297182

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Context Info
Confidence 0.60
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.52
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
heart 2
T-cells 1
Ppp3r1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 12 60.00 Quite High
fibrosis 24 30.16 Quite Low
anesthesia 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 54 99.78 Very High Very High Very High
Infection 18 97.66 Very High Very High Very High
Hyperplasia 30 96.56 Very High Very High Very High
Respiratory Failure 6 94.16 High High
Embryonic Lethality 6 83.56 Quite High
Death 18 79.40 Quite High
Arrhythmia Under Development 78 79.12 Quite High
Hypertrophy 12 68.00 Quite High
Sudden Death 24 52.64 Quite High
Cancer 12 49.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An adenovirus expressing Cre recombinase was used to delete CnB1 from MEFs containing the LoxP-targeted homozygous alleles, which reduced CnA and CnB1 protein levels by ?
Gene_expression (levels) of CnB1
1) Confidence 0.60 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0.24 Pain Relevance 0
Deletion of CnB1 in the developing thymocytes altered positive selection and the proper differentiation of T-cells, whereas deletion of CnB1 from neural crest cells altered Schwann cell differentiation, leading to myelination defects (20, 23).
Gene_expression (Deletion) of CnB1 in T-cells
2) Confidence 0.60 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0.32 Pain Relevance 0
Simultaneous infection with an adenovirus expressing the activated (truncated) form of CnA showed relatively stable expression even in the absence of CnB1 (Fig. 2C).
Neg (absence) Gene_expression (absence) of CnB1 associated with infection
3) Confidence 0.60 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0.22 Pain Relevance 0
In this study, we employed three different cardiac-expressing Cre transgenes to delete the CnB1 gene from the heart, each resulting in a slightly different failure phenotype.
Gene_expression (expressing) of CnB1 in heart
4) Confidence 0.54 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0.19 Pain Relevance 0
The Nkx2.5-Cre knock-in allele produced a very robust deletion of CnB1 from the heart, which resulted in a nearly complete loss of CnB and CnA protein from the heart as assayed at birth.
Gene_expression (produced) of CnB1 in heart associated with targeted disruption
5) Confidence 0.54 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0.19 Pain Relevance 0
Deletion of CnB1 with the ?
Gene_expression (Deletion) of CnB1
6) Confidence 0.52 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2825466 Disease Relevance 0.35 Pain Relevance 0.03

General Comments

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