INT2972

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Context Info
Confidence 0.36
First Reported 1979
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.95
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Olfr525) signal transducer activity (Olfr525)
Olfr525 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 5 99.24 Very High Very High Very High
tolerance 6 95.36 Very High Very High Very High
Morphine 1 89.92 High High
Intracerebroventricular 2 84.40 Quite High
diclofenac 2 84.36 Quite High
Physical dependence 3 76.32 Quite High
analgesia 1 75.00 Quite High
COX2 2 71.72 Quite High
cINOD 1 53.60 Quite High
narcan 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Hypothermia 6 98.36 Very High Very High Very High
Acne 4 82.80 Quite High
Drug Dependence 3 76.32 Quite High
INFLAMMATION 1 53.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of mice with phenobarbital, an inducer of oxidative drug metabolism, had no effect on the early hypothermic effect of a toxic dose of acetaminophen, while pretreatment with metyrapone, SKF-525A, or piperonyl butoxide (inhibitors of mixed-function oxidase) enhanced the hypothermia.
Negative_regulation (inhibitors) of SKF-525A associated with hypothermia and paracetamol
1) Confidence 0.36 Published 1982 Journal Toxicology Section Abstract Doc Link 7157399 Disease Relevance 0.47 Pain Relevance 0.46
Moreover, SKF-525A, a microsomal enzyme inhibitor, had little effect on the LAAM oral LD50 and the LAAM oral AD50, further indicating a minor role for dispositional tolerance.
Negative_regulation (inhibitor) of SKF-525A associated with tolerance
2) Confidence 0.03 Published 1979 Journal Drug Alcohol Depend Section Abstract Doc Link 574449 Disease Relevance 0.15 Pain Relevance 0.57
Furthermore, indomethacin and NS-398-augmented 15d-PGJ2 production and TG synthesis were suppressed by a non-selective cytochrome P-450 (CYP) inhibitor, SKF-525A.
Negative_regulation (inhibitor) of SKF-525A
3) Confidence 0.00 Published 2005 Journal J. Invest. Dermatol. Section Abstract Doc Link 16297182 Disease Relevance 0.34 Pain Relevance 0.17

General Comments

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