INT297229

Context Info Confidence 0.03 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.42

mitochondrion (Kcnj8) ATPase activity (Abcc8) plasma membrane (Abcc8) transmembrane transport (Abcc8)

Kcnj8 (Rattus norvegicus) Abcc8 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Spinal nerve ligature 23 80.40 Pain 9 50.00 isoflurane 3 37.12 anesthesia 4 36.24 unmyelinated 1 18.36 Neuropathic pain 8 5.00 Hyperalgesia 6 5.00 Neurotransmitter 3 5.00 withdrawal 2 5.00 nociceptor 2 5.00

Disease Link Frequency Relevance Heat Hypoxia 3 33.20 Nervous System Injury 9 5.00 Neuropathic Pain 9 5.00 Hyperalgesia 7 5.00 Injury 4 5.00 Death 2 5.00 Charcot Marie Tooth Disease 2 5.00 Ganglion Cysts 2 5.00 Pain 1 5.00 Nociception 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We identified this co-localization of Kir6.2 with SUR1 subunits by staining with antibody against Kir6.2, and with BODIPY-Glybenclamide, which specifically binds to SUR1 with high affinity at concentrations <40 nM [15].

Kir6 Binding (binds) of SUR1

1) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2825500 Disease Relevance 0 Pain Relevance 0.42

General Comments

This test has worked.