INT297241

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.02
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch1) Golgi apparatus (Notch1) plasma membrane (Notch1)
nucleus (Notch1) embryo development (Notch1) cytoplasm (Notch1)
Anatomy Link Frequency
dendrites 2
Notch1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 1 96.48 Very High Very High Very High
COX2 1 87.96 High High
Hippocampus 6 75.84 Quite High
cytokine 9 68.84 Quite High
Pyramidal cell 2 37.08 Quite Low
Thalamus 27 22.92 Low Low
alcohol 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Creutzfeldt Jakob Disease 36 94.12 High High
Cancer 70 78.16 Quite High
Sprains And Strains 5 76.88 Quite High
Pharynx Cancer 3 71.72 Quite High
Lymphatic System Cancer 1 60.88 Quite High
Epstein-barr Virus 15 60.20 Quite High
Papillomavirus Infection 19 56.72 Quite High
Thyroid Neoplasm 1 54.84 Quite High
Reprotox - General 1 1 52.88 Quite High
Skin Cancer 10 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based upon these studies, USC-HN1 demonstrated an increased level of activated Notch1 protein at levels equal to or higher than the Karpas 299 positive control (Figure 9).


Positive_regulation (increased) of Positive_regulation (increased) of Notch1
1) Confidence 0.40 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 0.78 Pain Relevance 0.11
Activation of Notch-1 stimulates the HES and HERP families of inhibitor effecter proteins [38], which in turn inhibit pro-neuronal genes that maintain the length and branching of dendrites.
Positive_regulation (stimulates) of Positive_regulation (Activation) of Notch-1 in dendrites
2) Confidence 0.14 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2825502 Disease Relevance 0.24 Pain Relevance 0.09

General Comments

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