INT297245

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.73
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp, Notch1) plasma membrane (Prnp, Notch1) nucleus (Prnp, Notch1)
cytoplasm (Prnp, Notch1) cell differentiation (Notch1) endoplasmic reticulum (Prnp)
Anatomy Link Frequency
Notch 1
Prnp (Mus musculus)
Notch1 (Mus musculus)
Pain Link Frequency Relevance Heat
Thalamus 27 31.88 Quite Low
Hippocampus 6 5.00 Very Low Very Low Very Low
Pyramidal cell 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Creutzfeldt Jakob Disease 36 91.84 High High
Scrapie 23 88.84 High High
Disease 23 86.40 High High
Kuru 2 75.32 Quite High
Death 7 56.84 Quite High
Infection 2 20.08 Low Low
Stress Incontinence 35 5.00 Very Low Very Low Very Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this article, we review the evidence that PrPSc accumulates in high concentration in membrane rafts, activates Notch-1 signaling and, in doing so, promotes neuronal dendritic degeneration.


PrPSc Positive_regulation (activates) of Notch-1 in Notch
1) Confidence 0.21 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2825502 Disease Relevance 0.73 Pain Relevance 0

General Comments

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