INT297258

Context Info Confidence 0.23 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.70 Pain Relevance 0.25

extracellular space (Agt) aging (Agt) extracellular region (Agt) plasma membrane (Agtr2) extracellular matrix organization (Agt) transcription factor binding (Agtr2)

Anatomy Link Frequency hippocampus 1 Agt (Rattus norvegicus) Agtr2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Hippocampus 6 97.00 cytokine 3 86.08 Inflammation 8 81.44 agonist 1 61.68 antagonist 3 5.00 ketamine 1 5.00 anesthesia 1 5.00 Bioavailability 1 5.00 addiction 1 5.00 Glutamate receptor 1 5.00

Disease Link Frequency Relevance Heat Injury 3 91.52 Apoptosis 10 82.64 INFLAMMATION 8 81.44 Neurodegenerative Disease 36 72.84 Necrosis 2 51.08 Cancer 1 50.72 Cognitive Disorder 6 5.00 Radiation Sickness 3 5.00 Hyperplasia 2 5.00 Demyelinating Disease 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Ang II is a potent vasopressor that exerts its effects by binding to G-protein receptors, AT1R and AT2R, which are broadly distributed in the brain and particularly dense in the hippocampus [23].

Ang II Binding (binding) of AT2R in hippocampus associated with hippocampus

1) Confidence 0.23 Published 2010 Journal Radiat Oncol Section Body Doc Link PMC2825515 Disease Relevance 0.70 Pain Relevance 0.25

General Comments

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