INT297286

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Context Info
Confidence 0.58
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.05
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Foxp3) intracellular (Foxp3) embryo development (Foxp3)
DNA binding (Foxp3) cytoplasm (Foxp3)
Anatomy Link Frequency
T cells 3
natural Tregs 1
thymus 1
regulatory T cells 1
Foxp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 117 96.24 Very High Very High Very High
tolerance 75 87.08 High High
chemokine 36 83.44 Quite High
Nerve growth factor 49 76.80 Quite High
cytokine 111 67.76 Quite High
ischemia 27 66.16 Quite High
Central nervous system 49 54.68 Quite High
Neuropeptide 1 40.32 Quite Low
substance P 8 38.56 Quite Low
addiction 1 20.28 Low Low
Disease Link Frequency Relevance Heat
Eczema 109 97.88 Very High Very High Very High
INFLAMMATION 135 96.24 Very High Very High Very High
Asthma 105 93.00 High High
Injury 169 92.52 High High
Disease 93 92.40 High High
Hypersensitivity 29 92.04 High High
Renal Disease 10 88.00 High High
Graft Vs Host Disease 11 87.36 High High
Organ Transplantation 4 84.12 Quite High
Leukopenia 2 68.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
mediated Foxp3 was inhibited by 1,25(OH)2D3 via the VDR signal on CD4+ T cells (Figure 4).
Positive_regulation (mediated) of Foxp3 in T cells
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.18 Pain Relevance 0.03
Through transduction with FoxP3, large numbers of Tregs (denoted here FoxP3-Tregs), whose properties resemble those of natural Tregs, can be generated for experimental purposes (22,23).
Positive_regulation (generated) of FoxP3 in natural Tregs
2) Confidence 0.31 Published 2010 Journal American Journal of Transplantation Section Body Doc Link PMC2856406 Disease Relevance 0.29 Pain Relevance 0.12
Subsequent adoptive transfer experiments, using naïve antigen-specific CD4+T cells, have revealed that in peptide tolerized WT animals there is an initial expansion of antigen-specific CD4+ T cells that have upregulated FoxP3, LAG3, CTLA4 and IFN-?
Positive_regulation (upregulated) of FoxP3 in T cells
3) Confidence 0.30 Published 2010 Journal European Journal of Immunology Section Body Doc Link PMC2988415 Disease Relevance 0.22 Pain Relevance 0.06
Tregs are identified by their expression of CD4 and CD25 on the cell surface and upregulation of the FoxP3, a unique marker for Treg cells that is essential for their development and function [109].
Positive_regulation (upregulation) of FoxP3
4) Confidence 0.27 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 0.93 Pain Relevance 0.15
Furthermore, Tregs are able to induce CD4+CD25-Foxp3- T cells and can even induce their own transformation into IL-17 producing cells when TGF-?
Positive_regulation (induce) of Foxp3 in T cells
5) Confidence 0.25 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.61 Pain Relevance 0.07
Fig. 7 shows schematically the action mechanism of FoxP3+CD25+CD4+ regulatory T cells, which are conceivable to suppress the induction and exacerbation of AD-like lesions through the suppression of IFN-?
Positive_regulation (regulatory T cells) of FoxP3 in regulatory T cells associated with eczema
6) Confidence 0.23 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 0.76 Pain Relevance 0.17
Dicer facilitates, in a cell-autonomous fashion, the development of Treg cells in the thymus and the efficient induction of Foxp3 by transforming growth factor-beta (TGF-?).
Positive_regulation (induction) of Foxp3 in thymus
7) Confidence 0.21 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.05 Pain Relevance 0.03

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