INT297288

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Context Info
Confidence 0.48
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.36
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl1) extracellular region (Cxcl1)
Anatomy Link Frequency
macrophages 2
T cells 2
Cxcl1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 30 100.00 Very High Very High Very High
cytokine 76 77.64 Quite High
Inflammation 74 62.60 Quite High
tolerance 3 44.64 Quite Low
ischemia 26 39.36 Quite Low
Inflammatory response 9 9.04 Low Low
antagonist 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 104 98.14 Very High Very High Very High
Injury 163 96.64 Very High Very High Very High
Hypersensitivity 24 84.64 Quite High
Disease 16 83.92 Quite High
Adhesions 14 69.04 Quite High
Genetic Predisposition To Disease 1 63.96 Quite High
INFLAMMATION 87 62.60 Quite High
Congenital Anomalies 1 43.64 Quite Low
Cv Unclassified Under Development 26 39.36 Quite Low
Autoimmune Disease 3 38.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of macrophage infiltration in the kidney using liposomal encapsulated clodronate prevented the increase in CXCL1 in the kidney suggesting that macrophages are the main source of CXCL1 in ischemic AKI.
Negative_regulation (prevented) of Positive_regulation (increase) of CXCL1 in macrophages associated with injury
1) Confidence 0.48 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.27 Pain Relevance 0.12
The question why CD4+/CD25+ T cells are reduced in asthmatic patients has not been answered yet; however, it has been observed that these cells reveal a reduced response to the chemokines CCL1 and CXCL1 suggesting an impaired recruitment to the lung [137, 138].
Negative_regulation (reduced) of Positive_regulation (response) of CXCL1 in T cells associated with asthma and chemokine
2) Confidence 0.36 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 1.09 Pain Relevance 0.12

General Comments

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