INT297316

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.92
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Rock2, Cdh1) plasma membrane (Rock2, Cdh1) endosome (Cdh1)
Golgi apparatus (Cdh1) cell adhesion (Cdh1) nucleus (Rock2)
Anatomy Link Frequency
kidney 2
Rock2 (Mus musculus)
Cdh1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 48 100.00 Very High Very High Very High
ischemia 26 100.00 Very High Very High Very High
chemokine 24 75.96 Quite High
Inflammatory response 8 70.80 Quite High
cytokine 31 60.32 Quite High
agonist 1 46.04 Quite Low
antagonist 3 9.36 Low Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 163 100.00 Very High Very High Very High
INFLAMMATION 60 100.00 Very High Very High Very High
Cv Unclassified Under Development 26 100.00 Very High Very High Very High
Reperfusion Injury 4 100.00 Very High Very High Very High
Fibrosis 2 100.00 Very High Very High Very High
Targeted Disruption 11 85.52 High High
Apoptosis 3 79.68 Quite High
Death 3 65.64 Quite High
Adhesions 12 59.60 Quite High
Endotoxemia 6 52.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of Rho kinase with the renally targeted Y27632-lysozyme conjugate strongly inhibits tubular damage, inflammation, and fibrogenesis induced by ischemia/reperfusion injury indicated by reduced staining of the dedifferentiation marker kidney injury marker-1 (KIM-1) and increased E-cadherin relative to controls [29].
Negative_regulation (Inhibition) of Rho kinase in kidney Positive_regulation (increased) of E-cadherin associated with fibrosis, reperfusion injury, inflammation, ischemia and injury
1) Confidence 0.01 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2825552 Disease Relevance 1.92 Pain Relevance 0.43

General Comments

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