INT297358

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.64
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
macrophages 1
fibroblasts 1


Pain Term Frequency Confidence Heat
cINOD 7 90.72 High High
agonist 33 83.16 Quite High
methotrexate 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
Osteogenic Sarcomas 79 93.08 High High
Apoptosis 26 92.96 High High
Disorder Of Lipid Metabolism 14 89.12 High High
Osteoporosis 17 85.20 High High
Disease 10 84.40 Quite High
Death 4 67.36 Quite High
Atherosclerosis 24 66.32 Quite High
Coronary Artery Disease 84 57.56 Quite High
Bladder Cancer 1 55.48 Quite High
Atherosclerotic Plaque 4 55.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of NPC1 function leads to defective suppression of sterol regulatory element binding protein (SREBP)-dependent gene expression and failure to appropriately activate liver X receptor-mediated pathways, ultimately resulting in intracellular cholesterol accumulation in macrophages and fibroblasts[7,8].
Gene_expression (expression) of SREBP in macrophages
1) Confidence 0.75 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2966454 Disease Relevance 0.66 Pain Relevance 0
-induced expression of C/EBP and ADD1/SREBP, suggesting that the drug resistance may occur through the inhibition of PPAR?
Gene_expression (expression) of SREBP
2) Confidence 0.58 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 1.32 Pain Relevance 0.35
Loss of NPC1 function leads to defective suppression of sterol regulatory element binding protein (SREBP)-dependent gene expression and failure to appropriately activate liver X receptor-mediated pathways, ultimately resulting in intracellular cholesterol accumulation in macrophages and fibroblasts[7,8].
Gene_expression (expression) of SREBP in fibroblasts
3) Confidence 0.26 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2966454 Disease Relevance 0.66 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox