INT29739

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Context Info
Confidence 0.69
First Reported 1988
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 4.37
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ANG) DNA binding (ANG) extracellular space (ANG)
extracellular region (ANG) cell death (ANG) nucleolus (ANG)
Anatomy Link Frequency
peritoneal fluid 3
endothelial cells 3
plasma 1
blood 1
nerve 1
ANG (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 152 98.16 Very High Very High Very High
bradykinin 36 97.26 Very High Very High Very High
Inflammation 43 96.80 Very High Very High Very High
Inflammatory mediators 6 88.20 High High
antagonist 9 86.24 High High
Angina 3 85.64 High High
tetrodotoxin 1 41.48 Quite Low
Enkephalin 2 25.00 Low Low
Bioavailability 4 13.28 Low Low
fibrosis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis 176 98.16 Very High Very High Very High
INFLAMMATION 48 96.80 Very High Very High Very High
Increased Venous Pressure Under Development 42 91.12 High High
Pre-eclampsia 66 90.68 High High
Coronary Artery Disease 15 87.16 High High
Cv General 3 Under Development 3 85.64 High High
Stress 5 79.04 Quite High
Atherosclerosis 41 78.44 Quite High
Renal Disease 16 73.84 Quite High
Myocardial Infarction 52 73.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results are in disagreement with recent reports (13, 14) demonstrating significant increases of angiogenin in the serum and peritoneal fluid in patients with endometriosis.
Positive_regulation (increases) of angiogenin in peritoneal fluid associated with endometriosis
1) Confidence 0.69 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.55 Pain Relevance 0.21
Alternatively, the elevated angiogenin levels in the peritoneal fluid of women with endometriosis may result from the inflammation processes associated with endometriosis.
Positive_regulation (elevated) of angiogenin in peritoneal fluid associated with endometriosis and inflammation
2) Confidence 0.69 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.70 Pain Relevance 0.25
Despite lack of data, it may also be speculated that an increased level of angiogenin in the circulating blood or peritoneal fluid promote the establishment of endometriotic lesions in the pelvic cavity, and once endometriotic lesions have been established and progressed to advanced stage, unknown adverse events, such as impairment of luteal steroidogenesis or release of local inflammatory mediators inhibiting response to progesterone, reduce the expression of angiogenin in the eutopic endometrium.
Positive_regulation (increased) of angiogenin in peritoneal fluid associated with endometriosis and inflammatory mediators
3) Confidence 0.69 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.71 Pain Relevance 0.23
Direct assay of NO liberation by bradykinin from endothelial cells was potentiated at 10 nmol/L concentration, 2.4-fold (Ang 1-9) and 2.1-fold (Ang 1-7); in higher concentrations, Ang 1-9 was significantly more active than Ang 1-7.
Positive_regulation (active) of Ang in endothelial cells associated with bradykinin
4) Confidence 0.62 Published 2002 Journal Hypertension Section Abstract Doc Link 12019279 Disease Relevance 0 Pain Relevance 0.18
Both drugs caused a decrease in angiotensin (Ang) II level, an increase in Ang I level, and reduction in Ang II/Ang I ratio in arterial and coronary sinus blood.
Positive_regulation (increase) of Ang in blood
5) Confidence 0.45 Published 2003 Journal Hypertension Section Abstract Doc Link 12623947 Disease Relevance 0.09 Pain Relevance 0.31
Direct assay of NO liberation by bradykinin from endothelial cells was potentiated at 10 nmol/L concentration, 2.4-fold (Ang 1-9) and 2.1-fold (Ang 1-7); in higher concentrations, Ang 1-9 was significantly more active than Ang 1-7.
Positive_regulation (active) of Ang in endothelial cells associated with bradykinin
6) Confidence 0.45 Published 2002 Journal Hypertension Section Abstract Doc Link 12019279 Disease Relevance 0 Pain Relevance 0.18
Although further studies are required to elucidate the relevance of angiogenin to the process of implantation, these findings suggest that the relative deficiency of angiogenin expression could be one of the critical factors involved in the mechanism by which endometriosis impairs fertility.



Positive_regulation (relevance) of angiogenin associated with endometriosis
7) Confidence 0.44 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.63 Pain Relevance 0.26
However, Ang-(1–7) does not change in the chorionic villi of preeclamptic women, whereas Ang II is increased; this suggests that the balance of these two biologically active peptides may be shifted toward the Ang II vasoconstrictor arm of the RAS[135].
Positive_regulation (increased) of Ang in arm
8) Confidence 0.43 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.26 Pain Relevance 0
The AT1-R and eNOS colocalize in the fetoplacental endothelial cells, and the AT1-R has been shown to mediate the Ang II increases in eNOS protein expression and NO production[96].
Positive_regulation (increases) of Ang in endothelial cells
9) Confidence 0.29 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.25 Pain Relevance 0
ANG II appears to be synthesized from ANG I via ANG converting enzyme in the primate arteries; the octapeptide potentiates the contraction caused by adrenergic nerve stimulation, possibly due to prejunctional ANG receptor activation and increased norepinephrine release.
Spec (possibly) Positive_regulation (activation) of ANG in nerve
10) Confidence 0.18 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2841452 Disease Relevance 0 Pain Relevance 0
Increased levels of Ang I and II could also lead to increased levels of biologically active Ang fragments.2 Therefore, direct renin inhibition may be a more optimal pharmacologic approach to RAAS inhibition by interrupting the system at its first regulated step.6
Positive_regulation (Increased) of Ang
11) Confidence 0.09 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952455 Disease Relevance 0.26 Pain Relevance 0.04
However, suppression of RAAS remains incomplete with these agents, due to the disruption of the negative feedback effect of Ang II on renin release, with a consequent increase in plasma renin activity (PRA) and reactive activation of the RAAS.5 Moreover, the increased Ang I levels seen with ACEIs can lead to “escape”, because Ang I is converted to Ang II by non-ACE pathways, mediated by chimase and chymotrypsin-like angiotensin-generating enzyme.
Positive_regulation (increased) of Ang in plasma
12) Confidence 0.09 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2952455 Disease Relevance 0.29 Pain Relevance 0.04
Furthermore, ANG II-induced sPLA2 activity and LDL-peroxidation were prevented by the sPLA2-IIA activity inhibitor LY311727 (Luchtefeld et al 2006).
Positive_regulation (induced) of ANG
13) Confidence 0.09 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 0.63 Pain Relevance 0.06

General Comments

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