INT29740

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Context Info
Confidence 0.78
First Reported 1988
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 55
Total Number 57
Disease Relevance 24.53
Pain Relevance 9.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ANG) DNA binding (ANG) extracellular space (ANG)
extracellular region (ANG) cell death (ANG) nucleolus (ANG)
Anatomy Link Frequency
endometrium 14
blood 4
placenta 4
endothelial cells 3
smooth muscle 2
ANG (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 1140 100.00 Very High Very High Very High
bradykinin 161 99.92 Very High Very High Very High
Inflammatory mediators 36 99.02 Very High Very High Very High
Inflammation 168 97.08 Very High Very High Very High
Enkephalin 56 96.60 Very High Very High Very High
Neuropeptide 241 95.76 Very High Very High Very High
Opioid 5 95.20 Very High Very High Very High
Pain 25 94.48 High High
substance P 3 90.28 High High
agonist 21 90.16 High High
Disease Link Frequency Relevance Heat
Endometriosis 1320 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 299 100.00 Very High Very High Very High
Pre-eclampsia 363 99.88 Very High Very High Very High
Sickle Cell Anemia 4 99.64 Very High Very High Very High
Necrosis 16 99.38 Very High Very High Very High
Cancer 77 99.20 Very High Very High Very High
Asthma 57 99.10 Very High Very High Very High
INFLAMMATION 210 98.82 Very High Very High Very High
Inflammatory Breast Neoplasms 8 97.72 Very High Very High Very High
Hypertension 264 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study was designed to compare the level of angiogenin expression in the eutopic endometrium from women with and without endometriosis by utilizing real-time polymerase chain reaction (PCR).


Gene_expression (expression) of angiogenin in endometrium associated with endometriosis
1) Confidence 0.78 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.63 Pain Relevance 0.25
Despite lack of data, it may also be speculated that an increased level of angiogenin in the circulating blood or peritoneal fluid promote the establishment of endometriotic lesions in the pelvic cavity, and once endometriotic lesions have been established and progressed to advanced stage, unknown adverse events, such as impairment of luteal steroidogenesis or release of local inflammatory mediators inhibiting response to progesterone, reduce the expression of angiogenin in the eutopic endometrium.
Gene_expression (expression) of angiogenin in peritoneal fluid associated with endometriosis and inflammatory mediators
2) Confidence 0.78 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.78 Pain Relevance 0.24
Although further studies are required to elucidate the relevance of angiogenin to the process of implantation, these findings suggest that the relative deficiency of angiogenin expression could be one of the critical factors involved in the mechanism by which endometriosis impairs fertility.



Gene_expression (expression) of angiogenin associated with endometriosis
3) Confidence 0.78 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.61 Pain Relevance 0.25
Despite these limits, we have found that the expression of angiogenin is decreased in the eutopic endometrium from women with advanced stage endometriosis during the normal window of implantation.
Gene_expression (expression) of angiogenin in endometrium associated with endometriosis
4) Confidence 0.78 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.82 Pain Relevance 0.26
It is possible that a relative deficiency of angiogenin expression in patients with advanced stage endometriosis leads to a defect in the angiogenic process that is essential for successful implantation.
Gene_expression (expression) of angiogenin associated with endometriosis
5) Confidence 0.78 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.27 Pain Relevance 0.10
Although it is very difficult to explain about the disagreement, it is possible that the expression of angiogenin in the eutopic endometrium is not regulated by the factors modulating the levels of circulating angiogenin.
Gene_expression (expression) of angiogenin in endometrium
6) Confidence 0.78 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.65 Pain Relevance 0.23
Based upon the specific enhancement of angiogenin expression around the implantation window period along with its strong angiogenic activity, it is necessary to investigate whether the expression of angiogenin in the eutopic endometrium is different between women with and without endometriosis.
Gene_expression (expression) of angiogenin in endometrium associated with endometriosis
7) Confidence 0.78 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.63 Pain Relevance 0.25
Angiogenin is expressed in human endometrium, with enhanced expression during the secretory phase, and in decidual tissues, raising the possibility that angiogenin may play a role in establishing pregnancy (6).
Gene_expression (expressed) of Angiogenin in endometrium
8) Confidence 0.78 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.53 Pain Relevance 0.22
It is possible that the expression of angiogenin in the eutopic endometrium might be quite different between the patients with stage I/II and III/IV endometriosis, considering that immune status, role of growth factors, and pathogeneses are notably different for stage I/II and III/IV endometriosis (15-17).
Gene_expression (expression) of angiogenin in endometrium associated with endometriosis
9) Confidence 0.78 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.87 Pain Relevance 0.25
Further studies utilizing in vitro cell culture or animal models for analyzing the expression level of angiogenin and other established markers for implantation could give a correct answer to this issue.
Spec (analyzing) Gene_expression (expression) of angiogenin
10) Confidence 0.78 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.41 Pain Relevance 0.16
At present, however, it is unclear whether the relative deficiency of angiogenin expression in the secretory phase is inherent to the eutopic endometrium itself or the secondary consequence of other factors associated with ovarian endometrioma.
Gene_expression (expression) of angiogenin in endometrium associated with endometriosis
11) Confidence 0.78 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.28 Pain Relevance 0.09
The findings of the present study suggest that the normal increase in angiogenin expression failed to occur during the implantation window period in the eutopic endometrium from women with advanced stage endometriosis.
Gene_expression (expression) of angiogenin in endometrium associated with endometriosis
12) Confidence 0.78 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.28 Pain Relevance 0.09
Based upon the specific enhancement of angiogenin expression around the implantation window period along with its strong angiogenic activity, it is necessary to investigate whether the expression of angiogenin in the eutopic endometrium is different between women with and without endometriosis.
Gene_expression (expression) of angiogenin in endometrium associated with endometriosis
13) Confidence 0.78 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.53 Pain Relevance 0.22
In addition, it has to be clarified whether angiogenin itself plays a critical role in the implantation window period or the expression of angiogenin in endometrial tissue is an epiphenomenon accompanying another critical event in the implantation window period.
Gene_expression (expression) of angiogenin
14) Confidence 0.78 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.32 Pain Relevance 0.11
Being well aware of the argument, we compared the level of angiogenin expression to evaluate whether there is a subtle difference between the two groups since some patients with endometriotic cyst can conceive easily without any treatment.
Gene_expression (expression) of angiogenin associated with endometriosis and cyst
15) Confidence 0.78 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2579997 Disease Relevance 0.85 Pain Relevance 0.14
In biopsies from asthmatic patients, Hoshino et al [52], showed higher expression of basic fibroblast growth factor (bFGF) and angiogenin, with significant correlations between the vascular area and the number of angiogenic factor-positive cells within the airways.
Gene_expression (expression) of angiogenin in fibroblast associated with asthma
16) Confidence 0.75 Published 2010 Journal Respir Res Section Body Doc Link PMC2955663 Disease Relevance 0.46 Pain Relevance 0.17
ACE plays a central role in the regulation of blood pressure (BP) through the production of the potent vasoconstrictor, angiotensin (Ang) II , and the degradation of the vasodilator, bradykinin (BK).
Gene_expression (production) of Ang in blood associated with bradykinin
17) Confidence 0.75 Published 2007 Journal Curr. Pharm. Des. Section Abstract Doc Link 17430180 Disease Relevance 0.09 Pain Relevance 0.22
Serum levels of angiopoietin (Ang)-1, Ang-2, vascular endothelial growth factor, placenta growth factor (PlGF), soluble tunica intima endothelial kinase 2 (sTIE2), erythropoietin (EPO) and endothelial activation markers (soluble vascular adhesion molecule-1, soluble intercellular adhesion molecule-1) were determined in controls, HbSS (n = 35) and HbSC (n = 23) patients.
Spec (determined) Gene_expression (levels) of Ang in tunica intima associated with adhesions
18) Confidence 0.65 Published 2006 Journal Br. J. Haematol. Section Abstract Doc Link 16803577 Disease Relevance 0.55 Pain Relevance 0.06
The products of Ang I cleavage, Ang 1-9 and Ang 1-7, potentiated the effect of an ACE-resistant bradykinin analog and enhanced kinin effect on the B(2) receptor in Chinese hamster ovary cells transfected to express human ACE and B(2) (CHO/AB), and in human pulmonary arterial endothelial cells.
Gene_expression (products) of Ang in endothelial cells associated with bradykinin
19) Confidence 0.60 Published 2002 Journal Hypertension Section Abstract Doc Link 12019279 Disease Relevance 0 Pain Relevance 0.11
The products of Ang I cleavage, Ang 1-9 and Ang 1-7, potentiated the effect of an ACE-resistant bradykinin analog and enhanced kinin effect on the B(2) receptor in Chinese hamster ovary cells transfected to express human ACE and B(2) (CHO/AB), and in human pulmonary arterial endothelial cells.
Gene_expression (products) of Ang in endothelial cells associated with bradykinin
20) Confidence 0.60 Published 2002 Journal Hypertension Section Abstract Doc Link 12019279 Disease Relevance 0 Pain Relevance 0.08

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