INT297421

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.60
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Flg) cytoskeleton organization (Flg)
Anatomy Link Frequency
alternatively activated macrophages 1
Flg (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 43 99.52 Very High Very High Very High
cytokine 19 87.48 High High
agonist 3 71.56 Quite High
Inflammatory response 10 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
member 8 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Francisella Infection 58 100.00 Very High Very High Very High
Sprains And Strains 38 99.96 Very High Very High Very High
INFLAMMATION 51 99.52 Very High Very High Very High
Dermatitis 6 98.40 Very High Very High Very High
Infection 47 80.04 Quite High
Disease 4 49.60 Quite Low
Aging 4 40.40 Quite Low
Acute-phase Reaction 1 28.76 Quite Low
Repression 1 24.08 Low Low
Acanthosis 8 20.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While alternatively activated macrophages display an anti-inflammatory phenotype, which might dampen Ft LVS-induced inflammation, they are unable to kill intracellular pathogens.
Spec (might) Positive_regulation (dampen) of Ft in alternatively activated macrophages associated with inflammation, sprains and strains and francisella infection
1) Confidence 0.40 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2826305 Disease Relevance 1.14 Pain Relevance 0.31
This was also the case for filaggrin, a gene that is mutated in a large percentage of patients with atopic dermatitis (Sandilands et al., 2009).
Positive_regulation (mutated) of filaggrin associated with dermatitis
2) Confidence 0.23 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.46 Pain Relevance 0.21

General Comments

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