INT297432

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.35
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ldlr) transport (Ldlr) aging (Ldlr)
plasma membrane (Ldlr) lipid metabolic process (Ldlr) lysosome (Ldlr)
Anatomy Link Frequency
fat 2
Ldlr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 2 61.40 Quite High
Glutamate 5 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperlipidemia 18 98.76 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

1 91.52 High High
Atherosclerosis 5 41.96 Quite Low
Porphyria 3 36.00 Quite Low
Disorder Of Lipid Metabolism 22 5.00 Very Low Very Low Very Low
Body Weight 10 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Toxicity 5 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 5 5.00 Very Low Very Low Very Low
Coronary Artery Disease 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, from the observation, the protective effect of the seeds of E. variegata on high fat induced hyperlipidemia may be attributed to a decrease in cholesterol synthesis, an increase in cholesterol excretion and expression of LDL receptor and subsequent catabolism.
Positive_regulation (increase) of Localization (excretion) of LDL receptor in fat associated with hyperlipidemia
1) Confidence 0.14 Published 2010 Journal Journal of Pharmacy and Bioallied Sciences Section Body Doc Link PMC2996074 Disease Relevance 0.26 Pain Relevance 0
At day 14, spectra from rats exposed to PB demonstrated a shift in the terminal methyl lipoprotein resonance to a lower chemical shift reflecting an increase in high density lipoprotein and decrease in low density lipoprotein as has been reported in PB-exposed Sprague Dawley rats [29].


Positive_regulation (increase) of Localization (decrease) of low density lipoprotein
2) Confidence 0.10 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2826316 Disease Relevance 0 Pain Relevance 0.03

General Comments

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