INT29745

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Context Info
Confidence 0.48
First Reported 1988
Last Reported 2010
Negated 5
Speculated 1
Reported most in Body
Documents 47
Total Number 48
Disease Relevance 26.49
Pain Relevance 12.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (APP) extracellular matrix organization (APP) DNA binding (APP)
cytoplasm (APP) cytosol (APP) extracellular region (APP)
Anatomy Link Frequency
cleavage 4
plaques 4
macrophage 2
Notch 1
plasma 1
APP (Homo sapiens)
Pain Link Frequency Relevance Heat
Abeta 132 100.00 Very High Very High Very High
cytokine 42 100.00 Very High Very High Very High
Kappa opioid receptor 3 100.00 Very High Very High Very High
tetrodotoxin 1 100.00 Very High Very High Very High
cINOD 105 99.82 Very High Very High Very High
aspirin 16 99.60 Very High Very High Very High
COX2 3 98.84 Very High Very High Very High
cOX1 2 98.84 Very High Very High Very High
Inflammatory response 12 98.44 Very High Very High Very High
palliative 3 97.02 Very High Very High Very High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 243 100.00 Very High Very High Very High
Amyloid Plaque 51 100.00 Very High Very High Very High
Cognitive Disorder 46 100.00 Very High Very High Very High
Immunization 5 100.00 Very High Very High Very High
Aneurism 1 100.00 Very High Very High Very High
Toxicity 10 99.98 Very High Very High Very High
INFLAMMATION 271 99.70 Very High Very High Very High
Targeted Disruption 86 99.70 Very High Very High Very High
Inclusion Body Myositis 7 99.60 Very High Very High Very High
Disease 433 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Remarkably, the same NSAIDs reported to alter gamma-secretase activity in Alzheimer's disease also reduce macrophage activation after platelet phagocytosis and inhibit formation of Abeta-containing peptides.
Abeta Binding (formation) of in macrophage associated with cinod, disease and abeta
1) Confidence 0.48 Published 2006 Journal Cardiovascular & hematological disorders drug targets Section Abstract Doc Link 16724933 Disease Relevance 0.92 Pain Relevance 0.46
Platelet phagocytosis, resulting in macrophage activation and iNOS induction, was associated with the formation of amyloid-beta peptide (Abeta) via proteolytic cleavage of platelet-derived amyloid precursor protein (APP), possibly by secretases.
Abeta Binding (formation) of in cleavage associated with alzheimer's dementia and abeta
2) Confidence 0.48 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15076232 Disease Relevance 0.52 Pain Relevance 0.35
In addition to binding to Notch2, APP is known to bind to many other proteins and therefore other types of APP heterodimers can potentially exist.
APP Binding (binding) of
3) Confidence 0.47 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.08 Pain Relevance 0
Aspirin prevented enhanced Abeta aggregation by aluminum, an environmental risk factor for AD.
Abeta Binding (aggregation) of associated with aspirin, disease and abeta
4) Confidence 0.42 Published 2001 Journal Neuroreport Section Abstract Doc Link 11711868 Disease Relevance 0.86 Pain Relevance 0.70
In addition, non-steroidal anti-inflammatory drugs (NSAIDs) and HMG-CoA reductase inhibitors (statins), two classes of drugs reported to affect APP processing and Abeta formation in Alzheimer's disease, have been evaluated for their capacity to inhibit macrophage activation evoked by platelet phagocytosis.
Abeta Binding (formation) of in macrophage associated with inflammation, cinod, disease and abeta
5) Confidence 0.37 Published 2006 Journal Cardiovascular & hematological disorders drug targets Section Abstract Doc Link 16724933 Disease Relevance 0.99 Pain Relevance 0.49
Platelet phagocytosis, resulting in macrophage activation and iNOS induction, was associated with the formation of amyloid-beta peptide (Abeta) via proteolytic cleavage of platelet-derived amyloid precursor protein (APP), possibly by secretases.
amyloid-beta peptide Binding (formation) of in cleavage associated with alzheimer's dementia and abeta
6) Confidence 0.37 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15076232 Disease Relevance 0.52 Pain Relevance 0.34
Platelet phagocytosis, resulting in macrophage activation and iNOS induction, was associated with the formation of amyloid-beta peptide (Abeta) via proteolytic cleavage of platelet-derived amyloid precursor protein (APP), possibly by secretases.
amyloid precursor protein Binding (associated) of in cleavage associated with alzheimer's dementia and abeta
7) Confidence 0.37 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15076232 Disease Relevance 0.53 Pain Relevance 0.36
Platelet phagocytosis, resulting in macrophage activation and iNOS induction, was associated with the formation of amyloid-beta peptide (Abeta) via proteolytic cleavage of platelet-derived amyloid precursor protein (APP), possibly by secretases.
APP Binding (associated) of in cleavage associated with alzheimer's dementia and abeta
8) Confidence 0.37 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 15076232 Disease Relevance 0.53 Pain Relevance 0.36
Interaction between APP and Notch2 was recently described and shown to occur in the ER, Golgi and at the plasma membrane [34,35].
APP Binding (Interaction) of in plasma
9) Confidence 0.36 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.07 Pain Relevance 0
SorL1 has also been shown to interact with BACE1 and it appears to compete with APP for interaction with BACE1 in the Golgi [50].
APP Binding (compete) of
10) Confidence 0.36 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.08 Pain Relevance 0
For evaluation of OSBP1, APP, and APP-CTFs expression levels in HEK-APPNFEV, cell monolayers were washed twice with ice-cold PBS and lysed in PBS containing 1% Triton X-100, 1 mM PMSF and Complete protease inhibitor cocktail (Roche, Indianapolis, IN) for 30 min on ice.
APP-CTFs Binding (evaluation) of
11) Confidence 0.36 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.06 Pain Relevance 0
For evaluation of OSBP1, APP, and APP-CTFs expression levels in HEK-APPNFEV, cell monolayers were washed twice with ice-cold PBS and lysed in PBS containing 1% Triton X-100, 1 mM PMSF and Complete protease inhibitor cocktail (Roche, Indianapolis, IN) for 30 min on ice.
APP Binding (evaluation) of
12) Confidence 0.36 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.06 Pain Relevance 0
The homodimerization of APP has been previously suggested to positively regulate A?
APP Binding (homodimerization) of
13) Confidence 0.36 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.06 Pain Relevance 0
To investigate this hypothesis we used bimolecular fluorescence complementation (BiFC), by which we have recently been able to identify interactions between APP-APP homodimers and APP-Notch heterodimers [34,35].
APP Binding (interactions) of in Notch
14) Confidence 0.36 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0 Pain Relevance 0
In this particular study our investigation was limited to APP-Notch2 heterodimers; however, this is likely only a small proportion of the total population of APP heterodimers, and it is possible that OSBP1 could also affect the intracellular trafficking of other types of APP heterodimers.
APP Binding (limited) of
15) Confidence 0.36 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.07 Pain Relevance 0
These effects were shown to occur via direct interaction between SorL1 and APP.
APP Binding (interaction) of
16) Confidence 0.36 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.09 Pain Relevance 0
The drug-induced decrease of membrane fluidity correlated with an increased association of APP and its beta-site cleaving enzyme BACE1 with detergent-resistant membranes (DRMs), which represent membrane clusters of substantial rigidity.
APP Binding (association) of
17) Confidence 0.36 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17395689 Disease Relevance 0.50 Pain Relevance 0
E9 mice to a diet high in omega-3 fatty acids, however, neither improved cognition in APPswe/PS1?
APP Neg (neither) Binding (cognition) of associated with cognitive disorder
18) Confidence 0.36 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952897 Disease Relevance 0.60 Pain Relevance 0
Transgenic expression of APPswe/ind and consequent overproduction of A?
APP Binding (ind) of associated with targeted disruption
19) Confidence 0.36 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283364 Disease Relevance 0.88 Pain Relevance 0.04
These findings suggest that isoflurane-induced Abeta oligomerization and apoptosis may contribute to the risk of postoperative cognitive dysfunction and provide a potential pathogenic link between delirium and dementia.


Abeta Binding (oligomerization) of
20) Confidence 0.36 Published 2006 Journal J. Gerontol. A Biol. Sci. Med. Sci. Section Body Doc Link 17234824 Disease Relevance 0.06 Pain Relevance 0

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