INT297489

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.16
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Ryr2)
Anatomy Link Frequency
spinal 4
Ryr2 (Rattus norvegicus)
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 136 100.00 Very High Very High Very High
Pain 18 99.40 Very High Very High Very High
agonist 16 92.88 High High
antagonist 20 91.92 High High
Hippocampus 6 89.84 High High
c fibre 26 89.76 High High
spinal dorsal horn 26 86.64 High High
Sciatic nerve 16 81.04 Quite High
Spinal cord 28 71.72 Quite High
dorsal root ganglion 38 63.92 Quite High
Disease Link Frequency Relevance Heat
Low Back Pain 10 99.68 Very High Very High Very High
Ganglion Cysts 38 63.92 Quite High
Nociception 6 50.00 Quite Low
Pain 10 28.68 Quite Low
Neuropathic Pain 2 20.36 Low Low
Hyperalgesia 4 19.80 Low Low
Li-fraumeni Syndrome 8 5.00 Very Low Very Low Very Low
Overdose 4 5.00 Very Low Very Low Very Low
Opiate Addiction 4 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Involvement of RyR, but not IP3R, in the induction of spinal LTP
RyR Regulation (Involvement) of Positive_regulation (induction) of LTP in spinal associated with long-term potentiation
1) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826347 Disease Relevance 0.06 Pain Relevance 0.68
To further confirm the involvement of RyR in the induction of LTP in the spinal pain pathway, we then performed electrophysiological recordings in vivo.
RyR Regulation (involvement) of Positive_regulation (induction) of LTP in spinal associated with low back pain, pain and long-term potentiation
2) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826347 Disease Relevance 0.10 Pain Relevance 0.96

General Comments

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