INT297507

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.63
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprk1) plasma membrane (Oprk1) signal transducer activity (Oprk1)
Oprk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 160 100.00 Very High Very High Very High
Lasting pain 2 99.98 Very High Very High Very High
trigeminal ganglion 44 95.00 High High
Dynorphin 16 94.48 High High
Central nervous system 48 91.84 High High
Inflammation 6 86.88 High High
Neuropathic pain 16 85.28 High High
Opioid 30 84.68 Quite High
Peripheral nerve injury 10 83.96 Quite High
antagonist 8 78.52 Quite High
Disease Link Frequency Relevance Heat
Pain 8 99.98 Very High Very High Very High
Ganglion Cysts 48 95.00 High High
Gliosis 10 92.64 High High
INFLAMMATION 6 86.88 High High
Neuropathic Pain 34 85.28 High High
Nervous System Injury 26 83.96 Quite High
Injury 2 50.00 Quite Low
Nociception 8 5.00 Very Low Very Low Very Low
Facial Pain 8 5.00 Very Low Very Low Very Low
Body Weight 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies [15,16,3] have shown that the sustained release of endogenous dynorphins during chronic pain increased KOR phosphorylation as detected by KOR-p staining.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of KOR associated with lasting pain and kappa opioid receptor
1) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.37 Pain Relevance 1.40
We previously established that activation of KOR results in G-protein receptor kinase mediated phosphorylation of KOR that can be readily detected using a phosphor selective antibody, KOR-p-IR [15].
Positive_regulation (mediated) of Phosphorylation (phosphorylation) of KOR associated with kappa opioid receptor
2) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.27 Pain Relevance 0.85

General Comments

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