INT297528

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Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.64
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (HAMP) cytoplasm (HAMP)
Anatomy Link Frequency
adipose tissue 1
HAMP (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 52 96.24 Very High Very High Very High
Inflammation 22 95.48 Very High Very High Very High
cytokine 22 59.48 Quite High
methotrexate 1 40.64 Quite Low
cINOD 2 38.92 Quite Low
visual analogue scale 3 23.20 Low Low
fibrosis 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Parenteral administration 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 1 99.84 Very High Very High Very High
Sickle Cell Anemia 86 98.30 Very High Very High Very High
Systemic Lupus Erythematosus 3 97.76 Very High Very High Very High
Disease 39 96.64 Very High Very High Very High
Rheumatoid Arthritis 53 96.24 Very High Very High Very High
INFLAMMATION 24 95.48 Very High Very High Very High
Anaemia 67 95.28 Very High Very High Very High
Hemolysis 3 89.84 High High
Iron-deficiency Anemia 2 85.20 High High
Infection 6 83.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, hepcidin mRNA level in adipose tissue correlates with IL-6 and C-reactive protein (CRP) (8).
Transcription (level) of hepcidin in adipose tissue associated with obesity
1) Confidence 0.69 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2826733 Disease Relevance 2.02 Pain Relevance 0.44
Although steady-state SCD patients do not exhibit increased hepcidin levels, transfusion acutely up regulates hepcidin mRNA expression [55].
Transcription (expression) of hepcidin associated with sickle cell anemia
2) Confidence 0.69 Published 2010 Journal Advances in Hematology Section Body Doc Link PMC2872757 Disease Relevance 1.35 Pain Relevance 0.05
As a consequence, the BMP/SMAD4 signalling pathway is hyperactive resulting in excess hepcidin transcription.
Transcription (transcription) of hepcidin
3) Confidence 0.16 Published 2010 Journal Biochemical Journal Section Body Doc Link PMC2958558 Disease Relevance 0 Pain Relevance 0
The disease is caused by mutations in the transmembrane serine protease TMPRSS6 (transmembrane protease serine 6) that prevent inactivation of HJV (haemojuvelin), an activator of hepcidin transcription.
Transcription (transcription) of hepcidin associated with disease
4) Confidence 0.13 Published 2010 Journal Biochemical Journal Section Abstract Doc Link PMC2958558 Disease Relevance 0.27 Pain Relevance 0

General Comments

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