INT297548

Context Info Confidence 0.05 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.20 Pain Relevance 0.10

DNA binding (Neurod1, Hes1) cytoplasm (Neurod1, Hes1) nucleus (Neurod1, Hes1) transcription factor binding (Neurod1, Hes1) cell differentiation (Neurod1) intracellular (Hes1)

Neurod1 (Mus musculus) Hes1 (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 13 74.32 dorsal root ganglion 1 49.28 Glutamate 10 6.64 cytokine 4 5.00 cerebral cortex 1 5.00 Nerve growth factor 1 5.00 Neuritis 1 5.00 ischemia 1 5.00 Neurotransmitter 1 5.00 alcohol 1 5.00

Disease Link Frequency Relevance Heat Neurodegenerative Disease 2 80.80 Rheumatoid Arthritis 7 63.36 Drug Induced Neurotoxicity 5 50.00 Ganglion Cysts 1 48.32 Death 13 5.12 Pressure And Volume Under Development 5 5.00 Injury 2 5.00 Disease 2 5.00 Neuritis 1 5.00 Toxicity 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These include transcription factors, such as Brain1 (Brn1), Numb, NeuroD, and downstream effectors of Notch1, Hes1, and Presenilin (18-22).

NeuroD Regulation (effectors) of Hes1

1) Confidence 0.05 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2826742 Disease Relevance 0.20 Pain Relevance 0.10

General Comments

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