INT297560

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.88
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (APOL1) transport (APOL1) extracellular space (APOL1)
extracellular region (APOL1) small molecule metabolic process (HSD11B1) oxidoreductase activity (HSD11B1)
Anatomy Link Frequency
blood 1
HSD11B1 (Homo sapiens)
APOL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 28 5.00 Very Low Very Low Very Low
Inflammation 18 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
pruritus 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 24 100.00 Very High Very High Very High
Pressure And Volume Under Development 4 50.88 Quite High
Toxicity 6 46.20 Quite Low
Sprains And Strains 14 43.52 Quite Low
Infection 106 7.36 Low Low
Trypanosomiasis 62 5.00 Very Low Very Low Very Low
Disease 52 5.00 Very Low Very Low Very Low
African Trypanosomiasis 44 5.00 Very Low Very Low Very Low
Parasitemia 28 5.00 Very Low Very Low Very Low
INFLAMMATION 26 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The APOL1 which is associated with HDL particles are internalized by the blood-stream form of trypanosomes via HDL-receptor mediated endocytosis in the flagellar pocket.
HDL Binding (associated) of APOL1 in blood associated with disorder of lipid metabolism
1) Confidence 0.04 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.42 Pain Relevance 0
This conformational change would cause a dissociation of the APOL1 from the HDL and leads to association with the lysosomal membrane.
HDL Binding (dissociation) of APOL1 associated with disorder of lipid metabolism
2) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2826769 Disease Relevance 0.47 Pain Relevance 0

General Comments

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