INT29759

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Context Info
Confidence 0.58
First Reported 1988
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.50
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nppa) nucleus (Nppa) cytoplasm (Nppa)
Anatomy Link Frequency
excretory 2
dopamine neurons 2
Nppa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 1 98.78 Very High Very High Very High
bradykinin 4 95.76 Very High Very High Very High
Catecholamine 2 92.48 High High
narcan 1 89.60 High High
Opioid 1 88.60 High High
Central nervous system 5 84.96 Quite High
anesthesia 2 82.56 Quite High
Morphine 2 77.08 Quite High
Disease Link Frequency Relevance Heat
Natriuresis 16 97.20 Very High Very High Very High
Diuresis 2 97.20 Very High Very High Very High
Body Weight 2 86.84 High High
Aging 1 53.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In all 3 cases, pretreatment with HOE-140 (2.5 microg IV) fully prevented the inhibition of ANP excretory action, ruling out osmotic effects as the cause of reduced diuresis.
Negative_regulation (prevented) of Negative_regulation (inhibition) of ANP in excretory associated with diuresis
1) Confidence 0.58 Published 1999 Journal Hypertension Section Abstract Doc Link 10523368 Disease Relevance 0.45 Pain Relevance 0.13
The present data suggest that the significantly reduced (about -20%) natriuretic and kaliuretic responses of the aged rat, observed 20 min after the onset of hypertonic volume expansion, could be partly due to a primary defect in cardiac production and/or release of ANF rather than to a reduction of renal responsivity to ANF.
Negative_regulation (defect) of Negative_regulation (reduction) of ANF associated with natriuresis
2) Confidence 0.43 Published 1996 Journal Gerontology Section Abstract Doc Link 9138977 Disease Relevance 0.53 Pain Relevance 0.15
When intravenous glucose infusion is omitted, the above-described inhibition of ANP does not take place.
Negative_regulation (above-described) of Negative_regulation (inhibition) of ANP
3) Confidence 0.43 Published 1999 Journal Hypertension Section Abstract Doc Link 10523368 Disease Relevance 0.39 Pain Relevance 0.17
Direct effects of ANF on tuberoinfundibular dopamine neurons are suggested by the observation that the prolactin-inhibiting action of ANF is prevented by domperidone treatment and is absent following alpha methyl-p-tyrosine inhibition of tyrosine hydroxylase activity.
Negative_regulation (prevented) of Negative_regulation (inhibiting) of ANF in dopamine neurons associated with dopamine
4) Confidence 0.24 Published 1988 Journal Brain Res. Bull. Section Abstract Doc Link 2842006 Disease Relevance 0.13 Pain Relevance 0.44

General Comments

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