INT2976

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Context Info
Confidence 0.45
First Reported 1978
Last Reported 2010
Negated 2
Speculated 5
Reported most in Abstract
Documents 29
Total Number 33
Disease Relevance 8.56
Pain Relevance 9.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Bche) endoplasmic reticulum (Bche)
Anatomy Link Frequency
plasma 3
brain 2
spinal 2
PGE1 1
cerebrospinal fluid 1
Bche (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 37 100.00 Very High Very High Very High
intrathecal 13 100.00 Very High Very High Very High
agonist 10 100.00 Very High Very High Very High
Antinociceptive 3 99.98 Very High Very High Very High
Morphine 5 99.82 Very High Very High Very High
tolerance 4 99.62 Very High Very High Very High
Clonidine 32 99.36 Very High Very High Very High
Neurotransmitter 10 99.08 Very High Very High Very High
lidocaine 9 99.00 Very High Very High Very High
Pain 7 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cognitive Disorder 28 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 14 100.00 Very High Very High Very High
Alzheimer's Dementia 18 99.16 Very High Very High Very High
Stroke 5 99.04 Very High Very High Very High
Nociception 2 98.90 Very High Very High Very High
Poisoning 3 98.84 Very High Very High Very High
Pain 4 98.80 Very High Very High Very High
Nervous System Injury 1 98.68 Very High Very High Very High
Drug Induced Neurotoxicity 1 98.68 Very High Very High Very High
Amnesia 26 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study examined the impact of the centrally active cholinesterase inhibitor physostigmine, which enhances memory and central cholinergic activity, on brief shock-induced hypoalgesia on the tail-flick test using Sprague-Dawley rats.
Spec (examined) Regulation (impact) of cholinesterase in tail associated with shock, tail-flick and hypoalgesia
1) Confidence 0.45 Published 1998 Journal Neurobiol Learn Mem Section Abstract Doc Link 9774528 Disease Relevance 0.76 Pain Relevance 0.58
Effects of cholinesterase inhibitors on the spasmogenic action of acetate esters on rat uterus.
Regulation (Effects) of cholinesterase in uterus
2) Confidence 0.45 Published 1978 Journal Eur. J. Pharmacol. Section Title Doc Link 618734 Disease Relevance 0.05 Pain Relevance 0.10
BACKGROUND: This study determined the effect of intrathecally administered cholinesterase inhibitors, edrophonium and neostigmine, on nerve injury-induced, touch-evoked allodynia and identified the pharmacologic characteristics of this action.
Regulation (effect) of cholinesterase in nerve associated with nervous system injury and allodynia
3) Confidence 0.45 Published 1999 Journal Anesthesiology Section Abstract Doc Link 9952157 Disease Relevance 0.27 Pain Relevance 0.25
Acute and chronic effects of cholinesterase inhibitors and pilocarpine on the density and sensitivity of central and peripheral alpha 2-adrenoceptors.
Regulation (effects) of cholinesterase
4) Confidence 0.44 Published 1993 Journal Eur. J. Pharmacol. Section Title Doc Link 8102972 Disease Relevance 0.14 Pain Relevance 0.51
There is good evidence that cholinesterase inhibitors and memantine are modestly effective in the treatment of AD.
Regulation (effective) of cholinesterase associated with alzheimer's dementia
5) Confidence 0.44 Published 2005 Journal South. Med. J. Section Abstract Doc Link 16004170 Disease Relevance 0.87 Pain Relevance 0.09
Among these cases, 848 (84%) received a cholinesterase inhibitor in both the risk and reference periods, leaving 161 cases to inform our matched pairs analysis of individuals who had received a cholinesterase inhibitor in either the risk or reference period, but not both.
Regulation (received) of cholinesterase
6) Confidence 0.44 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2742897 Disease Relevance 0.07 Pain Relevance 0
The aim of this study was to examine the pharmacological effect of an intrathecal alpha-2 agonist and a cholinesterase inhibitor on the facilitated pain model induced by formalin injection and to determine the nature of drug interaction using an isobolographic analysis.
Spec (examine) Regulation (effect) of cholinesterase associated with pain, agonist and intrathecal
7) Confidence 0.44 Published 2001 Journal J. Korean Med. Sci. Section Abstract Doc Link 11511797 Disease Relevance 0.20 Pain Relevance 0.89
The proband in family 2 was not sequenced, but a relative was heterozygous for BCHE*FS126.
Regulation (heterozygous) of BCHE
8) Confidence 0.43 Published 2007 Journal Pharmacogenet. Genomics Section Body Doc Link 18075469 Disease Relevance 0 Pain Relevance 0
Two novel mutations in the BCHE gene in patients with prolonged duration of action of mivacurium or succinylcholine during anaesthesia.
Regulation (prolonged) of BCHE associated with anesthesia
9) Confidence 0.43 Published 2007 Journal Pharmacogenet. Genomics Section Title Doc Link 18075469 Disease Relevance 0 Pain Relevance 0.10
To characterize the receptor subtypes modulating nociceptive transmission, we first determined the antinociceptive effects of intrathecally administered muscarinic agonists (McN-A-343 and carbachol) and a cholinesterase inhibitor (neostigmine) in rats.
Spec (determined) Regulation (effects) of cholinesterase associated with nociception, agonist and antinociceptive
10) Confidence 0.41 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9322468 Disease Relevance 0.10 Pain Relevance 0.48
Cholinesterase inhibitors have been shown to be effective in the treatment of the cognitive, behavioral, and functional deficits of AD.
Regulation (effective) of Cholinesterase associated with cognitive disorder
11) Confidence 0.37 Published 2002 Journal Med. Clin. North Am. Section Abstract Doc Link 12171061 Disease Relevance 0.61 Pain Relevance 0.04
Effect of bupivacaine application on cholinesterase activities, total protein- and albumin concentration in serum and cerebrospinal fluid.
Regulation (Effect) of cholinesterase in cerebrospinal fluid
12) Confidence 0.36 Published 2002 Journal Scand. J. Clin. Lab. Invest. Section Title Doc Link 12512739 Disease Relevance 0 Pain Relevance 0.48
Effects of cholinesterase inhibitors and clonidine coadministration on rat cortex neurotransmitters in vivo.
Regulation (Effects) of cholinesterase in cortex associated with neurotransmitter and clonidine
13) Confidence 0.28 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 7562554 Disease Relevance 0 Pain Relevance 0.73
These data suggest that a combination of cholinergic and adrenergic drug may improve the pharmacological effect of the cholinesterase inhibitor on cortical neurotransmitters such as ACh-NE.
Regulation (effect) of cholinesterase associated with neurotransmitter
14) Confidence 0.28 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562554 Disease Relevance 0 Pain Relevance 0.71
Role of cholinesterase activity on pharmacodynamics of mivacurium preceded by pancuronium in elderly and young adults.
Regulation (Role) of cholinesterase associated with anesthesia
15) Confidence 0.27 Published 2007 Journal J Egypt Soc Parasitol Section Title Doc Link 17580581 Disease Relevance 0 Pain Relevance 0.33
Cholinesterase activities, total protein- and albumin concentrations in serum as well as in cerebrospinal fluid were significantly decreased after surgical intervention under spinal Bupivacaine anesthesia but remained unchanged following spinal Bupivacaine application without surgery.
Neg (unchanged) Regulation (unchanged) of Cholinesterase in spinal associated with anesthesia
16) Confidence 0.27 Published 2002 Journal Scand. J. Clin. Lab. Invest. Section Abstract Doc Link 12512739 Disease Relevance 0 Pain Relevance 0.65
To further control for confounding, we corrected for temporal changes in cholinesterase inhibitor use by matching each case with up to three control patients on the basis of an extensive disease risk index score.
Regulation (changes) of cholinesterase associated with disease
17) Confidence 0.26 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2742897 Disease Relevance 1.06 Pain Relevance 0.03
Drugs altering plasma cholinesterase activity have the potential to decrease hydrolysis of ester-type local anaesthetics.
Regulation (altering) of cholinesterase in plasma
18) Confidence 0.26 Published 1998 Journal Drug Saf Section Abstract Doc Link 9565736 Disease Relevance 0.61 Pain Relevance 0.24
Regulation of central muscarinic receptors after cholinesterase inhibition: effect of clonidine.
Regulation (Regulation) of cholinesterase associated with clonidine
19) Confidence 0.25 Published 1993 Journal Brain Res. Bull. Section Title Doc Link 8221166 Disease Relevance 0 Pain Relevance 0.20
Changes in plasma cholinesterase activity during the puerperium were studied in 16 women who received epidural analgesia for labour followed by vaginal delivery, and in five women who underwent elective Caesarean section under epidural analgesia.
Regulation (Changes) of cholinesterase in plasma associated with epidural and analgesia
20) Confidence 0.25 Published 1986 Journal Anaesthesia Section Abstract Doc Link 3963327 Disease Relevance 0.12 Pain Relevance 0.28

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