INT297614

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.56
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TSC1) nucleus (ZNF275) intracellular (ZNF275)
embryo development (TSC1) DNA binding (ZNF275) protein complex (TSC1)
ZNF275 (Homo sapiens)
TSC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 2 5.00 Very Low Very Low Very Low
pruritus 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 47 100.00 Very High Very High Very High
Myeloid Leukemia 18 92.40 High High
Non-small-cell Lung Cancer 8 90.88 High High
Hypocalcemia 1 83.40 Quite High
Hypoalbuminemia 2 82.64 Quite High
Vomiting 29 81.96 Quite High
Anorexia 4 81.24 Quite High
Fatigue 18 80.84 Quite High
Neurologic Gait Disorders 1 78.72 Quite High
Toxicity 11 77.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pre-clinical studies suggested that combining inhibitors of DNA methyltransferase (DNMT), 5-azacitidine (AZA), with inhibitors of HDAC, SNDX-275, synergistically induced re-expression of epigenetically-silenced tumor suppressor genes and had anti-tumor effect.
SNDX-275 Positive_regulation (induced) of Gene_expression (expression) of tumor suppressor associated with cancer
1) Confidence 0.00 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2827364 Disease Relevance 1.56 Pain Relevance 0

General Comments

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